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首页> 外文期刊>Clinical and experimental allergy : >High-affinity immunoglobulin E receptor expression is increased in large and small airways in fatal asthma.
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High-affinity immunoglobulin E receptor expression is increased in large and small airways in fatal asthma.

机译：在致命性哮喘中，无论大小，呼吸道中的高亲和力免疫球蛋白E受体表达都会增加。

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BACKGROUND: IgE and its high-affinity receptor FcvarepsilonRI play an important role in allergy and asthma. The distribution of FcvarepsilonRI expression in the airways and within the airway wall, however, is largely unknown. OBJECTIVE: In this study, we aimed to map the distribution of FcvarepsilonRI in different layers of large airways (LA) and small airways (SA) in lung tissue from non-smoking and smoking patients who died of asthma [fatal asthma (FA)] and non-smoking controls (CTR). METHODS: Postmortem lung tissue from 24 cases of non-smoking FA, 13 smoking FA patients and from 19 subjects who died of non-pulmonary causes (CTR) was immunohistochemically stained for FcvarepsilonRI and AA1 (mast cell tryptase marker). The expression of these markers was analysed in inner, muscle, and outer layers of both LA and SA by image analysis. RESULTS: FcvarepsilonRI expression was higher in non-smoking and smoking FA compared with CTR in the inner and outer layer of SA. In the outer layer of LA, FcvarepsilonRI expression was higher in non-smoking FA compared with CTR. AA1 was higher in non-smoking FA compared with smoking FA and CTR in the outer layer of the SA, which was correlated with FcvarepsilonRI in this layer. CONCLUSION: Our results show that the expression of FcvarepsilonRI is higher in both LA and SA in FA compared with CTR. These differences are predominantly found in the outer layer where they can be attributed in part to the increased mast cell numbers. These results indicate an increased capacity to mount IgE-mediated reactions in FA, both in LA and SA.
机译：背景：IgE及其高亲和力受体FcvarepsilonRI在过敏和哮喘中起重要作用。然而，FcvarepsilonRI表达在气道内和气道壁内的分布是未知的。目的：在这项研究中，我们旨在绘制在非吸烟和吸烟中死于哮喘[致命性哮喘（FA）]的肺组织中，FcvarepsilonRI在肺气道（LA）和小气道（SA）不同层的分布情况以及禁烟（CTR）。方法：对24例非吸烟FA，13例吸烟FA患者和19例因非肺源性（CTR）死亡的受试者的死后肺组织进行了FcvarepsilonRI和AA1（肥大细胞类胰蛋白酶标记）的免疫组织化学染色。通过图像分析，分析了这些标志物在LA和SA的内层，肌肉和外层中的表达。结果：非吸烟和吸烟FA中的FcvarepsilonRI表达高于SA内外层的CTR。在LA的外层，非吸烟FA中的FcvarepsilonRI表达高于CTR。与SA外层的吸烟FA和CTR相比，非吸烟FA中的AA1更高，这与这一层中的FcvarepsilonRI相关。结论：我们的结果表明，与CTR相比，FA中的LA和SA中FcvarepsilonRI的表达更高。这些差异主要在外层发现，在那里它们可以部分归因于肥大细胞数量的增加。这些结果表明在LA和SA中，FA中IgE介导的反应发生的能力增强。

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