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Interleukin-17: a new role in steroid hypo-responsiveness?

机译：白介素17：类固醇低反应性的新作用？

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The product of the NR3C1 gene, the glucocorticoid receptor, plays a crucial role in mediating immune function. The most prevalent translated form in humans is a 777-amino acid protein, which is able to act as a transcription factor, a function that is facilitated by two zinc fingers that constitute a DNA binding domain. Signalling through the receptor is complex and over recent years, elegant experiments to explore alternative splicing to yield GRalpha and beta isoforms by use of two splice acceptors within the ninth exon of GR and the use of variable translation initiation sites have revealed many GR isoforms. These isoforms have been shown to traffic differently to the nucleus and possess a range of transcriptional regulation capacities and target gene specificities [1]. Both alpha- and beta-spliced isoforms may display amino-terminal variability of the translated protein, thus generating a large number of protein isoforms from a single gene, even before the consideration of what effect the numerous known post-translational modifications have upon the function of these proteins.
机译：NR3C1基因的产物糖皮质激素受体在介导免疫功能中起关键作用。人类中最普遍的翻译形式是777个氨基酸的蛋白质，该蛋白质能够充当转录因子，该功能由构成DNA结合结构域的两个锌指促进。通过受体的信号传递是复杂的，并且近年来，通过在GR第九个外显子中使用两个剪接受体探索可变剪接产生GRα和β亚型的精巧实验以及可变翻译起始位点的使用已揭示出许多GR亚型。这些同工型已被证明以不同的方式运输到核，并具有一系列的转录调节能力和靶基因特异性[1]。即使在考虑众多已知的翻译后修饰对功能的影响之前，α和β剪接的同工型都可能显示翻译蛋白的氨基末端变异性，从而从单个基因产生大量的蛋白同工型。这些蛋白质。

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