• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response.
【24h】

Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response.

机译：对非甾体类抗炎药过敏的受试者的特征：反应模式。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently involved groups of medicines in hypersensitivity drug reactions. Two mechanisms can induce the reaction: immunological (sensitization) due to a specific IgE or T cell response and pharmacological (cyclooxygenase inhibition). The contribution of each of these mechanisms to the reactions is not well known. OBJECTIVE: To analyse a large group of subjects with confirmed hypersensitivity reactions to NSAIDs. METHODS: The drugs involved, the clinical entities induced and the time interval between drug intake and appearance of the reaction were studied. In cases where the diagnosis was not confirmed, a drug provocation test was carried out. Atopy status was also assessed with prick test and total IgE in serum. RESULTS: A total of 659 patients were finally considered to have had hypersensitivity reactions to NSAIDs; 76% had cross-intolerance (CI) and 24% were selective responders (SR). The most important drugs involved in CI were propionic acid derivatives, in most cases ibuprofen, and in SR pyrazolones. In CI, the most frequent clinical entity was urticaria and angio-oedema and to a lesser extent airway involvement. The skin and airways were both involved in an important proportion of cases. The most frequent entities in SR were urticaria and/or angio-oedema followed by anaphylaxis. Atopy was significantly associated in the CI group (P<0.005). CONCLUSION AND CLINICAL RELEVANCE: Cutaneous hypersensitivity reactions by CI to NSAIDs are the most frequent entities induced by these compounds. In addition to aspirin, other NSAIDs are taking on a predominant role. Atopy can be a predisposing factor in patients with CI.
机译：背景：非甾体类抗炎药（NSAIDs）是超敏反应药物中涉及最频繁的药物之一。两种机制可以诱导该反应：由于特定的IgE或T细胞反应引起的免疫学（致敏）和药理作用（环加氧酶抑制）。这些机制中的每一种对反应的贡献尚不清楚。目的：分析确认对NSAIDs有超敏反应的一大批受试者。方法：研究涉及的药物，诱发的临床实体以及药物摄入与反应出现之间的时间间隔。如果未确诊，则进行药物激发试验。还通过点刺试验和血清中的总IgE评估了特应性状态。结果：总共659例患者最终被认为对NSAIDs有超敏反应。 76％的患者有交叉耐受（CI），24％的患者为选择性反应者（SR）。 CI中最重要的药物是丙酸衍生物（大多数情况下是布洛芬）和SR吡唑啉酮。在CI中，最常见的临床症状是荨麻疹和血管性水肿，程度较小的气道受累。皮肤和呼吸道都参与了很大比例的病例。 SR中最常见的实体是荨麻疹和/或血管性水肿，然后是过敏反应。 CI组中特应性显着相关（P <0.005）。结论和临床意义：CI对NSAIDs的皮肤超敏反应是这些化合物引起的最常见的实体。除阿司匹林外，其他非甾体类抗炎药也起主要作用。特应性可能是CI患者的诱发因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号