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首页> 外文期刊>Clinical and experimental allergy : >Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.
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Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.

机译：半胱氨酸白三烯：过敏性鼻炎的多功能介体。

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摘要

Cysteinyl leukotrienes (CysLTs) are a family of inflammatory lipid mediators synthesized from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and macrophages. This article reviews the data for the role of CysLTs as multi-functional mediators in allergic rhinitis (AR). We review the evidence that: (1) CysLTs are released from inflammatory cells that participate in AR, (2) receptors for CysLTs are located in nasal tissue, (3) CysLTs are increased in patients with AR and are released following allergen exposure, (4) administration of CysLTs reproduces the symptoms of AR, (5) CysLTs play roles in the maturation, as well as tissue recruitment, of inflammatory cells, and (6) a complex inter-regulation between CysLTs and a variety of other inflammatory mediators exists.
机译：半胱氨酰白三烯（CysLTs）是由花生四烯酸通过多种细胞（包括肥大细胞，嗜酸性粒细胞，嗜碱性粒细胞和巨噬细胞）合成的炎性脂质介体家族。本文回顾了CysLTs在过敏性鼻炎（AR）中作为多功能介体的作用的数据。我们审查了以下证据：（1）CysLTs从参与AR的炎性细胞中释放出来;（2）CysLTs的受体位于鼻组织中;（3）ARs患者中CysLTs升高并在过敏原暴露后释放，（ 4）给予CysLTs可重现AR症状，（5）CysLTs在炎症细胞的成熟以及组织募集中发挥作用，并且（6）CysLTs与多种其他炎症介质之间存在复杂的相互调节作用。

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