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The temporal sequence of allergic sensitization and onset of infantile eczema.

机译：婴儿湿疹变态反应的时间序列。

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BACKGROUND: Eczema is commonly associated with sensitization in infants, but the causative role of sensitization in the development of eczema has been questioned. OBJECTIVE: To determine if allergic sensitization increases the risk of developing eczema, or alternatively, if eczema increases the risk of developing allergic sensitization. METHODS: We used data from the Melbourne Atopy Cohort Study, a prospective birth cohort of 552 infants with a family history of atopic disease. The main outcomes were risk of developing eczema from 6 months to 7 years of age in asymptomatic infants; and risk of developing sensitization, as measured by skin prick tests to milk, egg white, peanut, house dust mite, rye grass pollen and cat extracts, in previously unsensitized infants. RESULTS: Sensitization to food extracts at 6 months was associated with an increased risk of developing eczema [hazard ratio (HR) 1.63, 95% confidence interval 1.13-2.35] up to 7 years of age, after excluding infants with eczema in the first 6 months. However, eczema in the first 6 months was also associated with increased risk of new sensitization at both 1 year (HR 2.34, 1.38-3.98) and 2 years (HR 3.47, 1.65-7.32). CONCLUSION: In some infants, sensitization precedes and predicts the development of eczema, while in others eczema precedes and predicts the development of sensitization. This indicates that there are multiple pathways to atopic eczema.
机译：背景：湿疹通常与婴儿的致敏作用有关，但人们对致敏作用在湿疹发展中的作用提出了质疑。目的：确定过敏性致敏是否增加了发生湿疹的风险，或者湿疹是否增加了致敏性过敏的风险。方法：我们使用了墨尔本特应性队列研究的数据，该研究为552例具有特应性疾病家族史的婴儿的前瞻性出生队列。主要结果是无症状婴儿从6个月至7岁出现湿疹的风险。通过对以前未致敏的婴儿的牛奶，蛋清，花生，屋尘螨，黑麦草花粉和猫提取物进行皮肤点刺试验，可以测量出致敏的风险。结果：在6个月内排除婴儿湿疹后，对6个月食物提取物的过敏与发生湿疹的风险增加[危险比（HR）1.63，95％置信区间1.13-2.35]高达7岁。个月。但是，头6个月的湿疹也与1年（HR 2.34，1.38-3.98）和2年（HR 3.47，1.65-7.32）的新致敏风险增加有关。结论：在某些婴儿中，致敏先于并预示着湿疹的发展，而在另一些婴儿中，湿疹先于并预示着敏化的发展。这表明异位性湿疹有多种途径。

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