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首页> 外文期刊>Clinical and experimental allergy : >The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability.
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The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability.

机译：基于HealthNuts人群的儿科食物过敏研究：有效性，安全性和可接受性。

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BACKGROUND: The incidence of hospital admissions for food allergy-related anaphylaxis in Australia has increased, in line with world-wide trends. However, a valid measure of food allergy prevalence and risk factor data from a population-based study is still lacking. OBJECTIVE: To describe the study design and methods used to recruit infants from a population for skin prick testing and oral food challenges, and the use of preliminary data to investigate the extent to which the study sample is representative of the target population. METHODS: The study sampling frame design comprises 12-month-old infants presenting for routine scheduled vaccination at immunization clinics in Melbourne, Australia. We compared demographic features of participating families to population summary statistics from the Victorian Perinatal census database, and administered a survey to those non-responders who chose not to participate in the study. RESULTS: Study design proved acceptable to the community with good uptake (response rate 73.4%), with 2171 participants recruited. Demographic information on the study population mirrored the Victorian population with most the population parameters measured falling within our confidence intervals (CI). Use of a non-responder questionnaire revealed that a higher proportion of infants who declined to participate (non-responders) were already eating and tolerating peanuts, than those agreeing to participate (54.4%; 95% CI 50.8, 58.0 vs. 27.4%; 95% CI 25.5, 29.3 among participants). CONCLUSION: A high proportion of individuals approached in a community setting participated in a food allergy study. The study population differed from the eligible sample in relation to family history of allergy and prior consumption and peanut tolerance, providing some insights into the internal validity of the sample. The study exhibited external validity on general demographics to all births in Victoria.
机译：背景：与世界范围内的趋势相一致，澳大利亚因食物过敏相关过敏反应而入院的人数有所增加。但是，仍然缺乏基于人群的研究对食物过敏发生率和危险因素数据的有效度量。目的：描述用于从人群中招募婴儿进行皮肤点刺试验和口服食物挑战的研究设计和方法，并使用初步数据调查研究样本代表目标人群的程度。方法：研究抽样框架设计包括12个月大的婴儿，他们在澳大利亚墨尔本的免疫诊所接受常规的定期疫苗接种。我们将参与家庭的人口统计学特征与维多利亚州围产期人口普查数据库中的人口汇总统计数据进行了比较，并对选择不参加该研究的无应答者进行了调查。结果：研究设计被社区认可，具有良好的吸收作用（回应率73.4％），招募了2171名参与者。研究人群的人口统计学信息反映了维多利亚州的人口，其所测得的大多数人口参数均在我们的置信区间（CI）内。使用无反应者问卷调查表明，拒绝参与（无反应者）的婴儿已经在进食和耐受花生的比例高于同意参与的婴儿（54.4％; 95％CI 50.8、58.0与27.4％; 52％CI。 95％CI 25.5，参与者中29.3）。结论：在社区环境中接触的很大一部分人参加了食物过敏研究。在过敏的家族史，既往食用和花生耐受性方面，研究人群与合格样本不同，从而为样本的内部有效性提供了一些见识。该研究在维多利亚州所有婴儿的总体人口统计数据上显示出外部有效性。

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