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首页> 外文期刊>Clinical and experimental allergy : >Lupin allergy: a hidden killer in the home.
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Lupin allergy: a hidden killer in the home.

机译：羽扇豆过敏：家庭中的隐藏杀手。

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摘要

This review addresses the problem of lupin sensitization in the home environment. We summarize the data currently available on allergy to lupin, which has become, in recent years, a hidden killer in our homes. Since 2006, when lupin was included in European regulations as a food whose presence must be declared, the situation may have changed. Nevertheless, we must take into account the possibility of undeclared allergenic ingredients or the presence of 'hidden' allergens, given that contamination during food production processes may be a great risk for sensitized individuals. Furthermore, the United States, Japan, Australia and New Zealand still do not include lupin among the ingredients that must be listed on foodstuff labelling. Our responsibility is to educate the public so that they are aware of the danger and look for lupin in the labels of products that run the risk of containing it. Lupin allergy can manifest itself in isolation or in parallel to peanut allergy. Identification of the proteins causing possible cross-reactivity is complicated, and new structural studies are needed. To date, it has not been possible to clearly identify the allergens responsible for isolated lupin sensitization in relation to parallel and/or cross-sensitization between lupin and peanut. Most of the allergenic proteins of lupin are alpha- and beta-conglutins, with a lesser presence of gamma- and delta-conglutins. A beta-conglutin corresponding to Lup an 1, with a sequence similar to Ara h 1, has been identified as a major allergen of lupin in patients with allergy following lupin ingestion.
机译：这篇评论解决了家庭环境中对羽扇豆过敏的问题。我们总结了目前对羽扇豆过敏的可用数据，近年来，羽扇豆已成为我们家庭中的隐性杀手。自2006年以来，羽扇豆被列为欧洲法规中的一种食品，必须宣布其存在，这种情况可能已经改变。但是，由于食品生产过程中的污染对于敏感人群而言可能是巨大的风险，因此，我们必须考虑未声明的致敏成分或“隐藏”过敏原的可能性。此外，美国，日本，澳大利亚和新西兰仍未在食品标签上列出羽扇豆成分。我们的责任是对公众进行教育，使他们意识到危险，并在存在限制危险的产品标签中寻找羽扇豆。羽扇豆过敏可单独或与花生过敏同时出现。鉴定可能引起交叉反应的蛋白质非常复杂，需要进行新的结构研究。迄今为止，还没有关于羽扇豆和花生之间的平行和/或交叉致敏作用，清楚地识别引起孤立的羽扇豆致敏作用的过敏原。羽扇豆的大多数致敏蛋白是α-和β-粘连蛋白，而γ-和δ-粘连蛋白较少。与羽扇豆1相似的L-an-1序列（与Ara h 1相似）已被确定是摄入羽扇豆后过敏的患者的羽扇豆主要过敏原。

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