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Wheat-dependent exercise-induced anaphylaxis: Pros and cons of recombinant ω-5gliadin and glutenins, or their epitope peptides, in diagnosis

机译：小麦依赖性运动引起的过敏反应：重组ω-5麦醇溶蛋白和谷蛋白或其表位肽在诊断中的利弊

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摘要

Wheat {Triticum aestivum) one of the major cereals, is essential in daily nutrition for a majority of people worldwide, but its ingestion can trigger adverse reactions, most often presenting as igE-mediated food hypersensitivity or T-cell mediated gluten enteropathy -coeliac disease. IgE-mediated hypersensitivity reactions to wheat proteins are clinically distinct dependent on the route of allergen exposure, target organs, and involve immunological mechanisms. They may manifest as a traditional food allergy to ingested wheat proteins (including cutaneous, gastrointestinal, and respiratory symptoms), as wheat-dependent exercise-induced ana-phylaxis (WDEIA) - when gluten intake is followed by exercise or occupational (baker's) asthma and rhinitis reactions to inhaled flour. In contrast, coeliac disease (gluten-sensitive enteropathy) is a genetically predisposed (HLA-DQ2/DQ8 restricted) disease, mediated by autoimmune mechanisms.
机译：小麦（Triticum aestivum）是主要谷物之一，对全世界大多数人的日常营养都是必不可少的，但其摄入会引起不良反应，最常见的表现为igE介导的食物超敏反应或T细胞介导的面筋肠病-乳糜泻。 IgE介导的对小麦蛋白的超敏反应在临床上取决于变应原暴露的途径，靶器官和涉及免疫学机制而有所不同。它们可能表现为对摄入的小麦蛋白（包括皮肤，胃肠道和呼吸道症状）的传统食物过敏，表现为小麦依赖性运动诱发的过敏反应（WDEIA）-当摄入麸质后进行运动或职业（面包师）哮喘和鼻炎对吸入面粉的反应。相反，腹腔疾病（麸质敏感性肠病）是遗传性疾病（HLA-DQ2 / DQ8限制），由自身免疫机制介导。

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