• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >VEGFA variants are associated with pre-school lung function, but not neonatal lung function
【24h】

VEGFA variants are associated with pre-school lung function, but not neonatal lung function

机译：VEGFA变异与学龄前肺功能有关，但与新生儿肺功能无关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary: Background: Vascular endothelial growth factor (VEGF) is implicated in airway remodelling and asthma development. We studied VEGFA gene variants and plasma levels and the development of lung function, bronchial hyperresponsiveness and asthma in childhood. Methods: We analysed 13 SNPs in the VEGFA gene in 411 children from the COPSAC2000 high-risk birth cohort. Asthma was diagnosed prospectively, and lung function measurements were obtained at birth and 6 years of age. Plasma VEGF levels were measured at 18 months of age. We used a Bonferroni adjusted significance level. Findings were replicated in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort at age 8. Results: At age six, three SNPs from the same linkage block were associated with FEV1 (rs699947, P = 1.31E-05), independent of asthma, and there were suggestive associations between FEV1/FVC ratio and rs833052 and maximal mid-expiratory flow and rs6900017. Replication in the PIAMA cohort showed borderline association between FEV1 and rs699947 and significant meta-analysis result. SNPs upstream and nearby rs699947 were nominally associated with VEGF plasma levels. VEGF levels were not associated with asthmatic symptoms or lung function measures. Conclusions and Clinical Relevance: VEGF gene variants are associated with lung function at school age, but not at birth, suggesting a role of VEGF in post-natal lung function development.
机译：摘要：背景：血管内皮生长因子（VEGF）参与气道重塑和哮喘的发展。我们研究了VEGFA基因变异和血浆水平以及儿童肺功能，支气管高反应性和哮喘的发展。方法：我们分析了来自COPSAC2000高危出生队列的411名儿童的VEGFA基因中的13个SNP。可对哮喘进行前瞻性诊断，并在出生时和6岁时获得肺功能测量结果。在18个月大时测量血浆VEGF水平。我们使用了Bonferroni调整的显着性水平。研究结果在8岁时的哮喘和螨虫过敏预防和发病队列（PIAMA）中得到了重复。结果：在6岁时，来自同一连锁区的三个SNP与FEV1相关（rs699947，P = 1.31E-05），与哮喘无关，FEV1 / FVC比值与rs833052，最大呼气中期流量和rs6900017之间存在暗示性关联。在PIAMA队列中的复制显示FEV1和rs699947之间存在边界关联，并且具有显着的荟萃分析结果。 rs699947上游和附近的SNP在名义上与VEGF血浆水平相关。 VEGF水平与哮喘症状或肺功能指标无关。结论和临床意义：VEGF基因变异与学龄期肺功能相关，但与出生时无关，这提示VEGF在出生后肺功能发育中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号