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首页> 外文期刊>Clinical and experimental allergy : >Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: A case-control study
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Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: A case-control study

机译：蠕虫感染和年龄对过敏原特异性IgE，皮肤测试反应性和喘息之间关联的影响：病例对照研究

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Background: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age. Objective: To explore the effects of geohelminth infections and age on atopy, wheeze, and the association between atopy and wheeze. Methods: A case-control study was done in 376 subjects (149 cases and 227 controls) aged 7-19 years living in rural communities in Ecuador. Wheeze cases, identified from a large cross-sectional survey, had recent wheeze and controls were a random sample of those without wheeze. Atopy was measured by the presence of allergen-specific IgE (asIgE) and skin prick test (SPT) responses to house dust mite and cockroach. Geohelminth infections were measured in stools and anti-Ascaris IgE in plasma. Results: The fraction of recent wheeze attributable to anti-Ascaris IgE was 45.9%, while those for SPT and asIgE were 10.0% and 10.5% respectively. The association between atopy and wheeze was greater in adolescents than children. Although Anti-Ascaris IgE was strongly associated with wheeze (adj. OR 2.24 (95% CI 1.33-3.78, P = 0.003) and with asIgE (adj. OR 5.34, 95% CI 2.49-11.45, P < 0.001), the association with wheeze was independent of asIgE. There was some evidence that the association between atopy and wheeze was greater in uninfected subjects compared with those with active geohelminth infections. Conclusions and clinical relevance: Atopy to house dust mite and cockroach explained few wheeze cases in our study population, while the presence of anti-Ascaris IgE was an important risk factor. Our data provided only limited evidence that active geohelminth infections attenuated the association between atopy and wheeze in endemic areas or that age modified this association. The role of allergic sensitization to Ascaris in the development of wheeze, independent of atopy, requires further investigation.
机译：背景：拉丁美洲贫困人口中的大多数儿童哮喘与气变应原致敏无关，这一现象可以通过慢性蠕虫感染或年龄的影响减轻过敏性反应来解释。目的：探讨地蠕虫感染和年龄对特应性，喘息以及特应性与喘息之间的关系的影响。方法：进行了一项病例对照研究，研究对象为居住在厄瓜多尔农村社区的7-19岁的376名受试者（149例和227名对照）。从大型横断面调查中发现的喘息病例最近有喘息，对照组是没有喘息的随机样本。通过过敏原特异性IgE（asIgE）的存在和对屋尘螨和蟑螂的皮肤点刺试验（SPT）响应来测量特应性。测量粪便中的蠕虫感染和血浆中的抗-虫IgE。结果：归因于抗A虫病的IgE引起的近期喘息比例为45.9％，而针对SPT和asIgE的喘息比例分别为10.0％和10.5％。青少年中，特应性与喘息之间的关联比儿童更大。尽管抗-虫病IgE与喘息密切相关（调节OR 2.24（95％CI 1.33-3.78，P = 0.003）和asIgE（调节OR 5.34，95％CI 2.49-11.45，P <0.001）结论和临床意义：房尘螨和蟑螂的特应性解释了本研究中极少发生喘息的病例，并与临床相关性：携带尘螨和蟑螂的特应性解释了很少的喘息病例。抗A虫IgE的存在是一个重要的危险因素，我们的数据仅提供了有限的证据，即活跃的蠕虫感染削弱了流行地区特应性和喘息的关联，或者年龄改变了这种关联。与特应性无关的喘息的发生需要进一步研究。

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