Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure

Croston T. L.; Nayak A. P.; Lemons A. R.; Goldsmith W. T.; Gu J. K.; Germolec D. R.; Beezhold D. H.; Green B. J.

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Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure

机译：亚慢性吸入暴露后烟曲霉分生孢子活力对小鼠肺微RNA和mRNA表达的影响

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Background Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. Objective The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia.

机译：背景技术个人暴露于源自受污染的建筑材料或农产品的真菌生物气溶胶可能诱发或加剧各种不利的健康影响。尚不清楚肺部对真菌生物气溶胶免疫反应基础的基因组机制。目的在亚慢性烟尘分生孢子孢子暴露后评估真菌活力对调节鼠类免疫应答的肺微RNA和信使RNA谱的影响。

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《Clinical and experimental allergy :》 |2016年第10期|共13页
作者
Croston T. L.; Nayak A. P.; Lemons A. R.; Goldsmith W. T.; Gu J. K.; Germolec D. R.; Beezhold D. H.; Green B. J.;
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正文语种 eng
中图分类医学免疫学;
关键词
allergens and epitopes; animal models; genetics;

机译：过敏原和表位;动物模型;遗传学;

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1. Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure [J] . Croston T. L., Nayak A. P., Lemons A. R., Clinical and experimental allergy : . 2016,第10期

机译：亚慢性吸入暴露后烟曲霉分生孢子活力对小鼠肺微RNA和mRNA表达的影响
2. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4+ T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10 [J] . Andrew B. Shreiner, Benjamin J. Murdock, Amir A. Sadighi Akha, Infection and immunity . 2012,第1期

机译：反复暴露于烟曲霉分生孢子会导致CD4 + T细胞依赖性和非依赖性肺动脉重塑在需要Thleu / Th2 / Th17混合微环境中需要白介素4（IL-4）和IL-10
3. Interleukin-17 Drives Pulmonary Eosinophilia following Repeated Exposure to Aspergillus fumigatus Conidia [J] . Benjamin J. Murdock, Nicole R. Falkowski, Andrew B. Shreiner, Infection and immunity . 2012,第4期

机译：反复暴露于烟曲霉分生孢子后，白细胞介素17驱动肺嗜酸性粒细胞增多
4. Different influence of Aspergillus fumigatus and Candida albioans on the expression of TLR9 by children granulocytes [C] . Bokonjic D., Miiller F.-M., Minic P., European Congress of Immunology . 2009

机译：曲霉和念珠菌与念珠菌对儿童粒细胞表达TLR9表达的不同影响
5. Immunoregulation and the role of IL-17 during chronic pulmonary exposure to Aspergillus fumigatus. [D] . Murdock, Benjamin Joseph. 2010

机译：长期暴露于烟曲霉中的免疫调节和IL-17的作用。
6. Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure [O] . Tara L. Croston, Ajay P. Nayak, Angela R. Lemons, -1

机译：亚慢性吸入暴露后烟曲霉分生孢子活力对小鼠肺微RNA和mRNA表达的影响
7. A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia. [O] . Amanda D Buskirk, Brett J Green, Angela R Lemons, 2014

机译：一种小鼠吸入模型，用于表征干燥烟曲霉分生孢子的肺部暴露。

Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure

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