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The association between infant feeding practices and subsequent atopy among children with a family history of asthma.

机译：有哮喘家族史的儿童中婴儿喂养方式与随后的特应性之间的关联。

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BACKGROUND: Although longer duration of breastfeeding and later introduction of solid foods are both recommended for the prevention of asthma and allergic disease, evidence to support these recommendations is controversial. OBJECTIVE: To examine the relation between infant feeding practices and the risk of asthma and allergic disease at age 5 years. METHODS: A cohort of children with a family history of asthma in Sydney, Australia, was followed from birth to age 5 years. Data on infant feeding practices and on early manifestations of eczema were collected prospectively. The presence of eczema, asthma and atopy (positive allergen skin prick tests) were determined at age 5 years. RESULTS: In 516 children evaluated at age 5 years, there was no significant association between the duration of breastfeeding or timing of introduction of solid foods and protection against asthma or other allergic disease, after adjustment for confounding factors. However, breastfeeding for 6 months or more and introduction of solid foods after 3 months were both associated with an increased risk of atopy at age 5 years (P=0.02 and 0.01, respectively). There was no significant association between the presence of eczema at 4 weeks and at 3 months and continued breastfeeding beyond those times. CONCLUSION: Longer duration of breastfeeding and later introduction of solid foods did not prevent the onset of asthma, eczema or atopy by age 5 years.
机译：背景：尽管建议均建议延长母乳喂养时间和以后再添加固体食物以预防哮喘和过敏性疾病，但支持这些建议的证据仍存在争议。目的：探讨婴儿喂养方式与5岁以下哮喘和过敏性疾病风险之间的关系。方法：从出生到5岁，对澳大利亚悉尼市有哮喘家族史的儿童进行追踪。前瞻性收集了有关婴儿喂养方式和湿疹早期表现的数据。在5岁时确定存在湿疹，哮喘和特应性（阳性过敏原皮肤点刺试验）。结果：在调整混杂因素后，在5岁以下接受评估的516名儿童中，母乳喂养的持续时间或固体食物的引入时间与对哮喘或其他过敏性疾病的保护之间没有显着关联。但是，母乳喂养6个月或更长时间以及3个月后引入固体食物都与5岁时的过敏性风险增加有关（分别为P = 0.02和0.01）。在第4周和第3个月出现湿疹与在这些时间之后继续母乳喂养之间没有显着关联。结论：更长的母乳喂养时间和后来引入固体食物并不能阻止5岁时哮喘，湿疹或特应性疾病的发作。

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