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首页> 外文期刊>Clinical and experimental allergy : >Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers.
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Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers.

机译：吸入白细胞介素5对哮喘和非哮喘性志愿者支气管和骨髓中嗜酸性粒细胞祖细胞的影响。

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Background Asthma is characterized by increases in mature eosinophils and their progenitors within the bronchus and bone marrow. IL-5 plays a key role in eosinophil development in the bone marrow and at the site of allergic inflammation. We therefore studied the effects of nebulized IL-5 on eosinophils, their progenitors and in situ haemopoiesis within the airway and bone marrow. Methods Nine atopic asthmatics and 10 non-atopic non-asthmatic control volunteers inhaled 10 mug of IL-5 or placebo via a nebulizer in a double-blind, randomized, cross-over study. Bronchoscopy, bone marrow aspiration and peripheral blood sampling were performed 24 h after nebulization. Four weeks later, volunteers inhaled the alternative solution and underwent a repeat bronchoscopy and bone marrow aspiration. Results Inhalation of IL-5 significantly decreased CD34(+)/IL-5Ralpha mRNA(+) cells within the bronchial mucosa and the percentage of CD34(+) cells that were CCR3(+) within the bone marrow of atopic asthmatic, but not control, volunteers. Inhalation of IL-5 also induced a significant increase in bronchial mucosal eosinophils in the non-atopic non-asthmatic control volunteers, but not in the asthmatics. IL-5 had no effect on spirometry or airways hyper-reactivity in either group. Conclusions Inhaled IL-5 modulated eosinophil progenitor numbers in both the airways and bone marrow of asthmatics and induced local eosinophilia in non-asthmatics.
机译：背景哮喘的特征是支气管和骨髓中成熟的嗜酸性粒细胞及其祖细胞增加。 IL-5在骨髓和过敏性炎症部位的嗜酸性粒细胞发展中起关键作用。因此，我们研究了雾化的IL-5对嗜酸性粒细胞，其祖细胞和气道和骨髓内原位造血的影响。方法在一项双盲，随机，交叉研究中，九名特应性哮喘患者和10名非特应性非哮喘对照志愿者通过雾化器吸入了10杯IL-5或安慰剂。雾化后24小时进行支气管镜检查，骨髓穿刺和外周血取样。四周后，志愿者吸入替代溶液，并再次进行了支气管镜检查和骨髓抽吸。结果吸入IL-5显着降低了特应性哮喘的支气管粘膜内CD34（+）/ IL-5Ralpha mRNA（+）细胞和CCR3（+）细胞中CD34（+）细胞的百分比，但未降低控制，志愿者。吸入IL-5在非异位性非哮喘控制志愿者中也诱导了支气管粘膜嗜酸性粒细胞的显着增加，但在哮喘患者中却没有。 IL-5对两组的肺活量测定或气道高反应性均无影响。结论哮喘患者气道和骨髓中吸入的IL-5调节嗜酸性粒细胞祖细胞数量，并在非哮喘患者中诱发局部嗜酸性粒细胞增多。

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