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首页> 外文期刊>Clinical and experimental allergy : >Increased expression of tissue vascular endothelial growth factor and foetal liver kinase-1 receptor in seasonal allergic rhinitis and relevance to asthma component.
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Increased expression of tissue vascular endothelial growth factor and foetal liver kinase-1 receptor in seasonal allergic rhinitis and relevance to asthma component.

机译：在季节性变应性鼻炎中组织血管内皮生长因子和胎儿肝激酶1受体的表达增加，并与哮喘成分有关。

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BACKGROUND: There is a difference in the extent of remodelling in allergic rhinitis (AR) and asthma. This may be attributed to the difference in local tissue response to these mediators. OBJECTIVES: The aim of this study was to compare vascular endothelial growth factor (VEGF) and its receptor foetal liver kinase (Flk)-1 expression between seasonal AR patients with or without asthma and non-allergic controls as well as that between AR patients with and without asthma. METHODS: Thirteen subjects with seasonal AR and six non-allergic controls were included in the study. Allergic sensitization was demonstrated by a skin prick test. Inferior turbinate thiny biopsies were obtained from both groups. Monoclonal mouse antibodies were used to demonstrate VEGF and Flk-1. Nasal mucosal endothelial cells' staining intensity was graded semi-quantitatively and the histochemical score (HSCORE) was calculated. In all samples, VEGF- and Flk-1-labelled vessels were counted for the assessment of vascular surface density (VSD). RESULTS: The mean HSCORE for VEGF and anti-VEGF-based VSD were significantly higher in the patient group (P=0.001 and 0.002, respectively). The mean HSCORE for Flk-1 and anti-Flk-1-based VSD in the patient group were significantly higher than those in the control group (P=0.016 and 0.028, respectively). Differences between the mean HSCORE for VEGF and anti-VEGF-based VSD in patients with pure AR and AR and asthma were insignificant (P=0.16 and 0.39, respectively). The mean HSCORE for Flk-1 and anti-Flk-1-based VSD in patients with pure AR were significantly lower than those in patients with AR and asthma (P=0.004 and 0.018, respectively). CONCLUSION: Angiogenic factor VEGF and its receptor Flk-1 is increased in AR. A similar increase in VEGF in AR with and without asthma despite a higher Flk-1 in AR patients with asthma may be a possible explanation for the presence of angiogenesis in the airway wall in patients with asthma but not in those with pure AR.
机译：背景：过敏性鼻炎（AR）和哮喘的重塑程度存在差异。这可能归因于局部组织对这些介质的反应的差异。目的：本研究的目的是比较季节性的AR患者（有或没有哮喘）与非过敏性对照以及患有AR的AR患者之间的血管内皮生长因子（VEGF）及其受体胎儿肝激酶（Flk）-1的表达。而且没有哮喘。方法：13名季节性AR患者和6名非过敏性对照者纳入研究。皮肤点刺试验证明过敏性致敏。两组均获得下鼻甲稀薄的活检组织。使用单克隆小鼠抗体来展示VEGF和Flk-1。对鼻黏膜内皮细胞的染色强度进行半定量分级，并计算组织化学评分（HSCORE）。在所有样品中，都对VEGF和Flk-1标记的血管计数，以评估血管表面密度（VSD）。结果：患者组中VEGF和基于抗VEGF的VSD的平均HSCORE显着更高（分别为P = 0.001和0.002）。患者组中基于Flk-1和基于抗Flk-1的VSD的平均HSCORE显着高于对照组（分别为P = 0.016和0.028）。单纯性AR和AR和哮喘患者中VEGF和基于抗VEGF的VSD的平均HSCORE之间的差异不显着（分别为P = 0.16和0.39）。单纯性AR患者的Flk-1和基于抗Flk-1的VSD的平均HSCORE显着低于AR和哮喘患者（分别为P = 0.004和0.018）。结论：AR中血管生成因子VEGF及其受体Flk-1增加。尽管患有哮喘的AR患者的Flk-1较高，但有哮喘和无哮喘的AR中VEGF的相似增加可能是哮喘患者气道壁存在血管生成的原因，而单纯AR患者则没有。

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