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首页> 外文期刊>Clinical and experimental allergy : >Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA).
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Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA).

机译：西班牙210名成年和小儿肥大细胞增多症患者的过敏和过敏症状患病率：西班牙关于肥大细胞增多症（REMA）网络的研究。

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BACKGROUND: Mast cells (MCs) play a key role in allergic diseases through the release of inflammatory mediators, which are responsible of allergic symptoms. Mastocytosis is characterized by an abnormal proliferation and accumulation of mast cells, in which mediators are released intermittingly or continuously. Despite these clinical similarities, few studies have addressed the presence of allergic symptoms in mastocytosis patients, including anaphylaxis. OBJECTIVE: A prospective evaluation was carried out to study the prevalence of allergic diseases in patients with mastocytosis and their impact on the natural history of mastocytosis. METHODS: A questionnaire was given to 210 patients with mastocytosis to evaluate the history of asthma, rhinitis, conjunctivitis, atopic dermatitis, urticaria and anaphylaxis. Patients underwent total IgE, Phadiatop infant (aeroallergens and food allergens), specific IgE to latex and to Anisakis simplex determinations. Skin tests were done to 72 patients. RESULTS: The prevalence of allergy, as defined by clinical symptoms associated to specific IgE, was 23.9%. Total IgE level was significantly higher in patients with allergy as compared with patients without allergy (median 58 vs. 16.5 kU/L, P<0.0001). Anaphylactic symptoms were present in 36 patients (22%), in nine the allergen was identified. Males had more allergy and anaphylactic symptoms than females (61.5% vs. 38.5% and 72% vs. 28%, respectively). CONCLUSIONS: Allergic diseases coexist in patients with mastocytosis with similar frequency as compared with the general population. Anaphylactic symptoms are more prevalent in males with mastocytosis and in patients with elevated IgE. CAPSULE SUMMARY: The prevalence of allergy in mastocytosis is similar to the general population. Anaphylactic symptoms are more prevalent in males and in patients with elevated IgE. The coexistence of atopy does not influence mastocytosis-associated symptoms.
机译：背景：肥大细胞（MC）通过释放炎症介质（在过敏性症状中起主要作用）在过敏性疾病中发挥关键作用。肥大细胞增多症的特征是肥大细胞的异常增殖和积累，其中的介质间歇或连续释放。尽管有这些临床相似之处，但很少有研究针对肥大细胞增多症患者（包括过敏反应）中存在过敏症状。目的：进行前瞻性评估，研究肥大细胞增多症患者的过敏性疾病患病率及其对肥大细胞增多症自然病程的影响。方法：对210名肥大细胞增多症患者进行了问卷调查，以评估其哮喘，鼻炎，结膜炎，特应性皮炎，荨麻疹和过敏反应的病史。患者接受总IgE，Phadiatop婴儿（空气过敏原和食物过敏原），乳胶和Anisakis单纯形抗体测定的特异性IgE。对72名患者进行了皮肤测试。结果：由与特定IgE相关的临床症状定义的过敏症患病率为23.9％。有过敏的患者的总IgE水平显着高于无过敏的患者（中位值58 vs. 16.5 kU / L，P <0.0001）。在36例患者（22％）中存在过敏症状，其中9例被鉴定为过敏原。男性比女性有更多的过敏和过敏症状（分别为61.5％，38.5％和72％与28％）。结论：肥大细胞增多症患者并存的过敏性疾病的发生频率与普通人群相似。过敏症状在肥大细胞增多的男性和IgE升高的患者中更为普遍。胶囊总结：肥大细胞增多症的过敏症患病率与一般人群相似。过敏症状在男性和IgE升高的患者中更为普遍。特应性的并存不影响肥大细胞增多症相关症状。

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