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Impact of cross-reactive carbohydrate determinants on wood dust sensitization

机译：交叉反应性碳水化合物决定因素对木屑敏感性的影响

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Background Occupational wood dust exposure can induce allergy and may be one cause of respiratory health problems among woodworkers.Objective The objective was to determine the prevalence and quantitative level of specific immunoglobulin E (slgE) to beech and pine wood in exposed workers. Wood sensitization was specified with regard to cross-reactivity and was correlated to the reported symptoms. Methods Danish workers (n = 701) were investigated for slgE to beech and pine. Wood samples from workplaces were analysed and coupled to ImmunoCAPs. Workers sensitized to wood were tested for cross-reactive carbohydrate determinants (CCDs) and environmental allergens. IgE binding was specified for glycogenic vs. proteinogenic epitopes by inhibition tests. Results The prevalence of wood sensitization among all workers was 3.7%. There was no association between sensitization prevalence or slgE concentrations and self-reported allergic symptoms. Beech- and pine-sensitized workers showed a high prevalence of CCD sensitization (73%). However, workers with a single sensitization to wood had no slgE to CCDs. Specifying IgE epitopes demonstrated that sera of workers reporting allergic symptoms recognized proteinogenic IgE-epitopes on wood allergens, whereas workers without allergic symptoms had primarily slgE-epitopes to glycogenic structures. Although 96?o of the wood-sensitized workers were atopic, no significant correlation was found between wood sensitization and slgE to beech and birch pollen, but an association was found between slgE against CCDs and pine pollen.Conclusion Sensitization prevalence to beech and pine wood measured by tailored ImmunoCAPs was not correlated to allergic symptoms. We recommend the application of CCD tools to assess the relevance of individual wood sensitization.
机译：背景职业性木粉尘暴露可能诱发过敏，可能是木工呼吸系统健康问题的原因之一。目的目的是确定暴露的工人中山毛榉木和松木中特定免疫球蛋白E（slgE）的患病率和定量水平。木材敏化度被指定为交叉反应性，并与报道的症状相关。方法调查了丹麦工人（n = 701）对山毛榉和松树的slgE含量。分析了来自工作场所的木材样品，并将其与ImmunoCAPs耦合。对木材敏感的工人进行了交叉反应性碳水化合物决定因子（CCD）和环境过敏原测试。通过抑制试验确定了糖原性与蛋白原性表位的IgE结合。结果所有工人中对木材过敏的患病率为3.7％。致敏率或slgE浓度与自我报告的过敏症状之间没有关联。对山毛榉和松木敏感的工人显示出很高的CCD致敏率（73％）。但是，对木材有单一敏化作用的工人对CCD的抵抗力却没有。指定IgE表位表明，报告过敏症状的工人血清可识别木材过敏原上的蛋白IgE表位，而没有过敏症状的工人主要具有糖原结构的slgE表位。尽管96例木材过敏工人中特应性过敏，但木材敏化度与slgE对山毛榉和桦木花粉的相关性未发现显着相关性，但slgE对CCD和松树花粉的相关性被发现。结论对山毛榉和松木的致敏性普遍存在量身定制的ImmunoCAP所测得的值与过敏症状无关。我们建议使用CCD工具来评估各个木材敏化的相关性。

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