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首页> 外文期刊>Clinical and experimental allergy : >Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years.
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Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years.

机译：4岁以下儿童的产前和产后接触抗生素以及湿疹，反复喘息和特应性过敏的发展。

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BACKGROUND: Little data are available on the relationship between indirect antibiotic exposure of the child in utero or during lactation and allergic diseases. On the other hand, several studies have been conducted on the association with direct post-natal antibiotic exposure, but the results are conflicting. OBJECTIVE: The aim of this study was to investigate pre- and post-natal antibiotic exposure and the subsequent development of eczema, recurrent wheeze and atopic sensitization in children up to the age of 4 years. METHODS: We conducted an aetiologic study in 773 children based on a prospective birth cohort project in which environmental and health information were collected using questionnaires. Antibiotic exposure was assessed as maternal antibiotic intake during pregnancy and during lactation and as medication intake of the child. The chronology of exposures and outcomes was taken into account during the data processing. At the age of 1 and 4 years, a blood sample was taken for the quantification of specific IgE. RESULTS: Prenatal antibiotic exposure was significantly positively associated with eczema, whereas no association was found with recurrent wheeze and atopic sensitization. We found a positive, although statistically not significant, association between antibiotic exposure through breastfeeding and recurrent wheeze. Neither eczema nor atopic sensitization was significantly associated with antibiotic exposure through breastfeeding. Finally, we observed a negative association between the use of antibiotics in the first year of life and eczema and atopic sensitization, and also between antibiotic use after the first year of life and recurrent wheeze, eczema and atopic sensitization. CONCLUSION: Indirect exposure to antibiotics (in utero and during lactation) increases the risk for allergic symptoms in children, while direct exposure to antibiotics appears to be protective. The biological mechanisms underlying these findings still need to be elucidated.
机译：背景：关于子宫内或哺乳期儿童间接抗生素暴露与过敏性疾病之间关系的数据很少。另一方面，已经进行了一些与直接出生后抗生素暴露相关的研究，但结果相矛盾。目的：本研究的目的是调查4岁以下儿童的产前和产后抗生素暴露以及随后的湿疹，反复喘息和特应性致敏的发展。方法：我们根据一项前瞻性出生队列项目对773名儿童进行了病因学研究，该项目使用问卷调查收集了环境和健康信息。抗生素暴露被评估为孕期和哺乳期的母体抗生素摄入量，以及儿童的药物摄入量。在数据处理过程中考虑了暴露和结果的时间顺序。在1岁和4岁时，采集血液样本以定量特定IgE。结果：产前抗生素暴露与湿疹呈显着正相关，而与反复发作的喘息和特应性致敏无关联。我们发现通过母乳喂养的抗生素暴露与反复发作的喘息之间存在正相关（尽管在统计学上不显着）。母乳喂养引起的湿疹和过敏性致敏都与抗生素暴露无显着相关性。最后，我们观察到在生命的第一年使用抗生素与湿疹和特应性致敏之间存在负相关，并且在生命的第一年之后使用抗生素与复发性喘息，湿疹和特应性致敏之间存在负相关。结论：间接接触抗生素（子宫内和哺乳期）会增加儿童过敏症状的风险，而直接接触抗生素似乎具有保护作用。这些发现背后的生物学机制仍需要阐明。

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