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首页> 外文期刊>Clinical and experimental allergy : >Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response
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Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response

机译：尽管存在寄生虫特异性细胞因子反应，但Trichuris suis ova疗法对过敏性鼻炎的治疗不会影响过敏原特异性细胞因子反应

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Background: Parasitic helminths have been shown to reduce inflammation in most experimental models of allergic disease, and this effect is mediated via cytokine responses. However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied. Objective: The aim was to investigate whether infection with the nematode parasite Trichuris suis alters systemic cytokine levels, cellular cytokine responses to parasite antigens and pollen allergens and/or the cytokine profile of allergic individuals. Methods: In a randomized double-blinded placebo-controlled clinical trial (UMIN trial registry, Registration no. R000001298, Trial ID UMIN000001070, URL: http://www.umin.ac.jp/map/english), adults with grass pollen-induced allergic rhinitis received three weekly doses of 2500 Trichuris suis ova (n = 45) or placebo (n = 44) over 6 months. IFN-γ, TNF-α, IL-4, IL-5, IL-10 and IL-13 were quantified via cytometric bead array in plasma. Cytokines, including active TGF-β, were also quantified in supernatants from peripheral blood mononuclear cells cultured with parasite antigens or pollen allergens before, during and after the grass pollen season for a sub-cohort of randomized participants (T. suis ova-treated, n = 12, Placebo-treated, n = 10). Results: Helminth infection induced a Th2-polarized cytokine response comprising elevated plasma IL-5 and parasite-specific IL-4, IL-5 and IL-13, and a global shift in the profile of systemic cytokine responses. Infection also elicited high levels of the regulatory cytokine IL-10 in response to T. suis antigens. Despite increased production of T. suis-specific cytokines in T. suis ova-treated participants, allergen-specific cytokine responses during the grass pollen season and the global profile of PBMC cytokine responses were not affected by T. suis ova treatment. Conclusions and Clinical Relevance: This study suggests that cytokines induced by Trichuris suis ova treatment do not alter allergic reactivity to pollen during the peak of allergic rhinitis symptoms.
机译：背景：在大多数变应性疾病的实验模型中，寄生虫蠕虫已被证明可以减轻炎症，这种作用是通过细胞因子反应介导的。但是，在人类中，尚未研究控制性蠕虫感染对过敏过程中细胞因子反应的影响。目的：研究线虫寄生虫Trichuris suis的感染是否会改变全身细胞因子水平，细胞因子对寄生虫抗原和花粉过敏原的反应和/或变应性个体的细胞因子谱。方法：在一项随机双盲安慰剂对照临床试验（UMIN试验注册，注册号R000001298，试验编号UMIN000001070，URL：http://www.umin.ac.jp/map/english）中，成年人患有草花粉引起的变应性鼻炎，在6个月内每周接受三剂2500头猪Trichuris suis ova（n = 45）或安慰剂（n = 44）。通过细胞计数珠阵列在血浆中对IFN-γ，TNF-α，IL-4，IL-5，IL-10和IL-13进行定量。在草花粉季节之前，期间和之后，随机分组的亚群（猪T. suis ova处理， n = 12，经安慰剂治疗，n = 10）。结果：蠕虫感染诱导了Th2极化的细胞因子反应，包括血浆IL-5和寄生虫特异性IL-4，IL-5和IL-13升高，以及全身细胞因子反应谱的整体变化。感染还引起对猪链球菌抗原的高水平调节性细胞因子IL-10。尽管在经猪链球菌治疗的参与者中猪链球菌特异性细胞因子的产量增加，但是在草花粉季节的过敏原特异性细胞因子应答和PBMC细胞因子应答的整体情况不受猪链球菌治疗的影响。结论和临床意义：这项研究表明，在过敏性鼻炎症状高峰期，猪Trichoris suis ova处理诱导的细胞因子不会改变对花粉的过敏反应性。

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