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首页> 外文期刊>Clinical and experimental allergy : >Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age
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Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age

机译：学龄前脐血Th2相关趋化因子CCL22水平与总IgE升高相关

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Background: Early-life immune deviation is suspected in the inception of atopic disease. Objective: To investigate the association between cord blood chemokines and the subsequent development of atopic biomarkers and clinical end-points during the first 6 years of life. Methods: The Th1-associated chemokines CXCL10 and CXCL11 and the Th2-associated chemokines CCL17 and CCL22 were assessed in cord blood of asymptomatic at-risk newborn children from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC 2000) birth cohort and associated with the longitudinal development of biomarkers and clinical end-points of asthma, eczema, and allergic rhinitis during the first 6 years of life. Results: Cord blood CCL22 levels were significantly associated to total-IgE levels measured at four time-points during the first 6 years of life; overall odds ratio, 1.54 [CI, 1.25-1.89; P 0.0001]. CXCL10 and CXCL11 were not associated with development of any atopic disorders or biomarkers. Conclusion and Clinical Relevance: High cord blood levels of the Th2 related chemokine CCL22 were significantly associated with high total- IgE levels during the first 6 years of life, but not with specific sensitization, asthma, eczema or allergic rhinitis. This suggests an inborn skewing of the immune system in healthy newborns developing elevated total- IgE later in life.
机译：背景：特应性疾病发作时怀疑有早期免疫缺陷。目的：研究脐血趋化因子与生命的最初6年中特应性生物标志物的后续发展和临床终点之间的关系。方法：在哥本哈根儿童哮喘前瞻性研究（COPSAC 2000）出生队列中，对无症状高危新生儿脐带血中的Th1相关趋化因子CXCL10和CXCL11以及Th2相关趋化因子CCL17和CCL22进行了评估。在生命的头6年中，生物标志物的纵向发展以及哮喘，湿疹和变应性鼻炎的临床终点。结果：脐血CCL22水平与生命最初6年中四个时间点测得的总IgE水平显着相关。总体比值比为1.54 [CI，1.25-1.89; P <0.0001]。 CXCL10和CXCL11与任何特应性疾病或生物标记的发生均无关。结论与临床意义：在生命的头6年中，Th2相关趋化因子CCL22的脐血高水平与总IgE高水平显着相关，但与特异性致敏，哮喘，湿疹或过敏性鼻炎无关。这表明健康的新生儿的先天性免疫系统倾斜，在以后的生命中总IgE升高。

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