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首页> 外文期刊>Clinical and experimental allergy : >Asthma induced by inhalation of flour in adults with food allergy to wheat.
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Asthma induced by inhalation of flour in adults with food allergy to wheat.

机译：在成年人中吸入面粉导致的哮喘，对小麦产生食物过敏。

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BACKGROUND: Wheat is one of the major food allergens and it is also an inhalant allergen in workers exposed to flour dusts. Food allergy to wheat in adulthood seems to be rare and has never been reported to be associated with asthma induced by flour inhalation. OBJECTIVE: The study aimed at detecting adults with food allergy to wheat and screening them for the presence of specific bronchial reactivity to inhaled wheat proteins. METHODS: Adults with a history of adverse reactions to ingestion of wheat underwent skin prick test with commercial wheat extract and were assessed for the presence of specific wheat IgE in the sera. Food sensitivity to wheat was confirmed by double-blind, placebo-controlled food challenge (DBPCFC). Specific bronchial reactivity was investigated through a specific bronchial challenge with wheat proteins. RESULTS: In nine patients with evidence of specific IgE response to wheat, a diagnosis of food allergy was made by DBPCFC. Only two subjects had asthma as disease induced by ingestion of wheat. Seven subjects reported a history of respiratory symptoms when exposed to flour dusts. A significant reduction of forced expiratory volume in 1 s (FEV(1)) was detected in these seven patients when a specific bronchial challenge with flour proteins was performed. Only three out of seven subjects with asthma induced by flour could be considered occupationally exposed to flour dusts. CONCLUSION: For the first time, it has been shown that specific bronchial reactivity to wheat proteins can be detected in patients with different disorders associated with food allergy to wheat. The presence of asthma induced by inhaled flour is not strictly related to occupational exposure and it may also occur in subjects not displaying asthma among symptoms induced by wheat ingestion.
机译：背景：小麦是主要的食物过敏原，也是暴露于面粉粉尘的工人的吸入性过敏原。成年后对小麦的食物过敏似乎很少见，从未有报道称与面粉吸入引起的哮喘有关。目的：该研究旨在检测对小麦食物过敏的成年人，并筛选他们是否存在对吸入的小麦蛋白的特异性支气管反应性。方法：对有摄入小麦不良反应史的成年人，用商品小麦提取物进行皮肤点刺试验，并评估其血清中是否存在特定小麦IgE。对小麦的食物敏感性已通过双盲，安慰剂对照食物挑战（DBPCFC）得到证实。通过用小麦蛋白进行特定的支气管攻击研究了特定的支气管反应性。结果：在9名对小麦有特定IgE反应证据的患者中，DBPCFC诊断出食物过敏。仅两名受试者患有因摄入小麦而诱发的哮喘。七个受试者报告了接触面粉粉尘后出现呼吸道症状的历史。当用面粉蛋白进行特定的支气管刺激时，这七名患者​​在1 s内发现强制呼气量显着减少（FEV（1））。在面粉诱发的哮喘患者中，只有七分之三被认为是职业性接触粉尘的人。结论：首次表明，在与小麦食物过敏相关的不同疾病患者中，可以检测到对小麦蛋白质的特异性支气管反应性。吸入面粉引起的哮喘的存在与职业暴露没有严格关系，在小麦摄入引起的症状中，未表现出哮喘的受试者中也可能发生哮喘。

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