• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.
【24h】

Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.

机译：哮喘中的丝裂原活化蛋白激酶信号传导和ERK1 / 2双稳态。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mitogen-activated protein kinases (MAPKs) integrate signals from numerous receptors and translate these signals into cell functions. MAPKs are critical for immune cell metabolism, migration, production of pro-inflammatory mediators, survival and differentiation. We provide a concise review of the involvement of MAPK in important cells of the immune system. Certain cell functions, e.g. production of pro-inflammatory mediators resolve quickly and may require a transient MAPK activation, other processes such as cell differentiation and long-term survival may require persistent MAPK signal. The persistent MAPK signal is frequently a consequence of positive feedback loops or double negative feedback loops which perpetuate the signal after removal of an external cell stimulus. This self-perpetuated activation of a signalling circuit is a manifestation of its bistability. Bistable systems can exist in 'on' and 'off' states and both states are stable. We have demonstrated the existence of self-perpetuated activation mechanism for ERK1/2 in bronchial epithelial cells. This sustained activation of ERK1/2 supports long-term survival of these cells and primes them for cytokine transcription. ERK1/2 bistability arises from repetitive stimulation of the cell. The repeated stimulation (e.g. repeated viral infection or repeated allergen exposure) seems to be a common theme in asthma and other chronic illnesses. We thus hypothesize that the self-perpetuated ERK1/2 signal plays an important role in the pathogenesis of asthma.
机译：丝裂原激活的蛋白激酶（MAPK）整合来自众多受体的信号，并将这些信号转化为细胞功能。 MAPK对免疫细胞代谢，迁移，促炎性介质的产生，存活和分化至关重要。我们提供了有关MAPK参与免疫系统重要细胞的简明综述。某些单元功能，例如促炎性介质的产生迅速分解，可能需要短暂的MAPK激活，其他过程（例如细胞分化和长期存活）可能需要持续的MAPK信号。持久性MAPK信号通常是正反馈回路或双负反馈回路的结果，这些信号会在去除外部细胞刺激后使信号永久存在。信号电路的这种自我延续的激活是其双稳态的体现。双稳态系统可以处于“开”和“关”状态，并且两种状态都是稳定的。我们已经证明在支气管上皮细胞中存在ERK1 / 2的自我持久的激活机制。 ERK1 / 2的这种持续活化支持了这些细胞的长期存活，并为细胞因子的转录做好了准备。 ERK1 / 2双稳态源自细胞的重复刺激。反复刺激（例如反复病毒感染或反复过敏原暴露）似乎是哮喘和其他慢性疾病的共同主题。因此，我们假设自我延续的ERK1 / 2信号在哮喘的发病机理中起着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号