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首页> 外文期刊>Clinical and experimental allergy : >Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence.
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Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence.

机译：青春期后代的母体产前食用花生以及对花生和黑麦的致敏作用。

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BACKGROUND: There is considerable controversy whether maternal peanut ingestion during pregnancy might influence sensitization in later life. Objective To examine whether maternal peanut ingestion during pregnancy might increase sensitization in the offspring. METHODS: A population-based longitudinal cohort study with 16 years follow-up was conducted (N=373). Subjects were recruited at birth as part of an infant health study. Maternal antenatal peanut consumption was documented at birth and peanut and rye sensitization were determined by measurement of serum-specific IgE at age 16. RESULTS: Peanut sensitization was common (14%). In the entire cohort (n=310), there was no association between antenatal peanut ingestion and peanut sensitization (P=0.17). However, there was a strong association between antenatal peanut ingestion and decreased risk of rye sensitization and peanut sensitization in those (n=201) without a family history (FH) of asthma (Rye OR 0.30, 95% CI 0.14-0.63, P=0.001 and Peanut OR 0.18, 95% CI 0.04-0.78, P=0.02). There was an increased risk of rye sensitization in those (n=108) with a FH of asthma and antenatal peanut ingestion (Rye OR 2.69, 95% CI 1.11-6.51 P=0.03). It was considered that these sensitizations were likely to be related to the presence of IgE antibodies to cross-reacting carbohydrate epitopes common to rye and peanut allergens. CONCLUSIONS AND CLINICAL RELEVANCE: Antenatal peanut ingestion may influence the development of IgE antibody to cross-reacting carbohydrate epitopes in later life. Genetic factors may modify this association.
机译：背景：怀孕期间母体花生的摄入是否会影响以后的致敏性存在很大争议。目的探讨孕期孕妇摄入花生是否可能增加后代的敏感性。方法：进行了一项基于人群的纵向队列研究，随访了16年（N = 373）。作为婴儿健康研究的一部分，招募了出生时的受试者。有孕妇记录产前食用花生，并在16岁时通过测定血清特异性IgE来测定花生和黑麦的致敏性。结果：花生致敏性很普遍（14％）。在整个队列（n = 310）中，产前花生摄入与花生敏化之间没有关联（P = 0.17）。但是，在没有哮喘家族史（FH）的那些人（n = 201）中，产前花生摄入与黑麦致敏和花生致敏风险降低之间有很强的联系（黑麦或0.30，95％CI 0.14-0.63，P = 0.001和花生OR 0.18，95％CI 0.04-0.78，P = 0.02）。患有FH哮喘和产前花生摄入的人群（n = 108）中黑麦致敏的风险增加（Rye OR 2.69，95％CI 1.11-6.51 P = 0.03）。人们认为这些致敏作用可能与针对黑麦和花生过敏原常见的交叉反应碳水化合物表位的IgE抗体的存在有关。结论和临床意义：产前摄入花生可能会影响以后生活中与交叉反应碳水化合物表位结合的IgE抗体的发育。遗传因素可能会改变这种关联。

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