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首页> 外文期刊>Clinical and experimental allergy : >Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy.
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Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy.

机译：脐带血清TARC / CCL17水平升高可预测婴儿特应性皮炎的发展。

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BACKGROUND: Thymus-and-activation-regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined. Objective Seventy paired full-term and normal vaginal delivery newborns and their mothers were enrolled in this study. METHODS: To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN-gamma-inducible protein 10 kDa (IP-10; CXCL10), soluble HLA-G (sHLA-G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples. RESULTS: Serum CCL17 (r(s) =0.340, P<0.001) and sHLA-G (r(s) =0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than in those without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6 pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6 pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8-98.7), specificity 73.8% (60.5-87.1), positive predictive value 68.6% (53.2-84.0) and negative predictive value 88.6% (78.0-99.1). CONCLUSION AND CLINICAL RELEVANCE: These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord blood may be a predictive marker for AD in infancy.
机译：背景：胸腺和激活调节趋化因子（TARC; CCL17）与变态反应和怀孕有关，但尚未检查母体和脐带血CCL17与特应性皮炎（AD）发展的关系。目的纳入70例成对的足月和正常阴道分娩新生儿及其母亲。方法：为阐明婴儿期AD的发病机理和胎儿母体遗传，使用血清检查了CCL17，IFN-γ诱导蛋白10 kDa（IP-10; CXCL10），可溶性HLA-G（sHLA-G），IgE和嗜酸性粒细胞计数从70对配对的脐带和孕妇血液样本中提取。结果：血清CCL17（r = 0.340，P <0.001）和sHLA-G（r = 0.600，P <0.001）水平显示脐带与母血之间存在高度相关性。注定要在婴儿期发展为AD的新生儿的脐带血清CCL17水平要比婴儿期没有AD迹象的新生儿的脐带血CCL17水平更高（中位数1586.9 vs. 819.6 pg / mL，P <0.001）。患有AD的母亲的血清CCL17水平高于没有AD的母亲（中值909.6 vs. 214.1 pg / mL，P <0.001）。即使在62例无AD的母亲出生的新生儿中，脐带血CCL17的高水平也与婴儿AD的发生有关（中位数1514.4 vs. 740.6 pg / mL，P <0.001）和38例无过敏的母亲出生的新生儿（中位数1624.2vs。 740.6 pg / mL，P <0.001）。脐带血清CCL17在婴儿AD诊断中的简要估算为：敏感性85.7％（95％置信区间：72.8-98.7），特异性73.8％（60.5-87.1），阳性预测值68.6％（53.2-84.0）和阴性预测值88.6％（78.0-99.1）。结论和临床意义：这些发现表明脐带血CCL17可能参与了婴幼儿AD的发病机制和母系遗传。脐带血的血清CCL17水平可能是婴儿期AD的预测指标。

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