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Weight loss in children with asthma improves asthma control and quality of life

机译：哮喘儿童的体重减轻可改善哮喘控制和生活质量

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Obesity has been associated with poor asthma control, increased exacerbation risk and reduced response to inhaled corticosteroids in children and adults [1, 2]. Although our understanding of how weight gain or obesity affects asthma remains limited, it is becoming evident that this complex association is not determined by increased allergic airway inflammation [3]. Furthermore, this multifactorial relationship probably does not affect all obese asthmatics alike [4, 5]. There are cases in which obesity may be the result, rather than the cause of severe asthma [6]; in others, obesity might be predominantly a symptom burden that contributes to a diagnostic bias [7]. Yet in others, obesity may adversely influence asthma pathophysiology and or response to steroids [8]. What determines which of these obese-asthma relationship exists in a given patient may depend on other phenotypical characteristics such as age of asthma onset, the duration of obesity, gender and underlying genotypes. However, regardless of the specific mechanisms or the type of obese-asthma phenotype, weight loss improves asthma control as shown in the study by Jensen et al. in this issue of the journal [9].
机译：肥胖与儿童和成人哮喘控制不良，加重病情加重和对吸入糖皮质激素的反应降低有关[1，2]。尽管我们对体重增加或肥胖如何影响哮喘的理解仍然很有限，但是越来越明显的是，这种复杂的关联并不取决于过敏性气道炎症的增加[3]。此外，这种多因素关系可能不会像所有肥胖肥胖症患者一样影响[4，5]。在某些情况下，可能是肥胖而不是导致严重哮喘的原因[6]。在其他人中，肥胖可能主要是导致诊断偏倚的症状负担[7]。然而，在其他人中，肥胖可能会对哮喘的病理生理和/或对类固醇的反应产生不利影响[8]。确定哪些肥胖与哮喘关系存在于特定患者中的决定因素可能取决于其他表型特征，例如哮喘发作的年龄，肥胖的持续时间，性别和基本基因型。然而，无论肥胖机制的具体机制或类型如何，减肥都能改善哮喘的控制，正如詹森等人的研究表明的那样。在本期杂志[9]中。

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