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首页> 外文期刊>Clinical and experimental allergy : >The prevalence of PFS and prevalence and characteristics of reported food allergy; a survey of UK adults aged 18-75 incorporating a validated PFS diagnostic questionnaire
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The prevalence of PFS and prevalence and characteristics of reported food allergy; a survey of UK adults aged 18-75 incorporating a validated PFS diagnostic questionnaire

机译：PFS的患病率和所报告的食物过敏的患病率和特征;对英国18-75岁成年人进行的一项调查，其中纳入了经过验证的PFS诊断问卷

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摘要

Background: Pollen-food syndrome (PFS), a food allergy affecting pollen-sensitized individuals, is likely to be the most prevalent food allergy in adults, estimated to affect 50-90% of people allergic to birch tree pollen. Objective: A validated PFS diagnostic questionnaire (PFSDQ2) was used to determine the prevalence of PFS and also to characterize those who report reactions to foods. Methods: Five UK General practices each sent the PFSDQ2 by post to 2000 patients aged 18-75 years randomly selected from their practice database. The validated questionnaire was accompanied by an additional set of questions to ascertain the demographic of the population, the foods involved and the age of onset. Results: There were 3590 subjects who returned completed questionnaires, with an average return rate from each practice of 36% (range 22-47%). Of these, 73 were diagnosed with PFS according to the questionnaire (PFS+ve) giving a population prevalence of 2%. A further 482 subjects reported reactions to foods but did not fulfil the diagnostic criteria for PFS. The greatest prevalence of PFS was in the Croydon (SE England) urban practice (4.1%) and the lowest in the Aberdeen (Scotland) urban practice (0.8%) (P < 0.001).The most frequently reported trigger foods were apples, hazelnuts and kiwifruit and the majority of those with PFS first experienced symptoms below the age of 20 years. PFS+ve subjects were also more likely to be female and have a higher socio-economic status than those who did not report reactions to foods. Conclusions: The UK prevalence of PFS was 2%, although this varied according to the location of the practice population. The majority of PFS+ve subjects first reported symptoms in their teens. The reported age of onset has important implications for the diagnosis of primary and cross-reactive peanut and tree nut allergies in teenagers and young adults. The continuing rise in aeroallergen sensitization is likely to result in an increased frequency of PFS presenting in both primary and secondary care.
机译：背景：花粉食物综合症（PFS）是一种影响花粉敏感人群的食物过敏，很可能是成年人中最普遍的食物过敏，估计会影响对桦树花粉过敏的50-90％的人。目的：使用经过验证的PFS诊断调查表（PFSDQ2）来确定PFS的患病率，并确定报告食物反应的人的特征。方法：五种英国普通科医师通过邮寄方式从他们的执科医师数据库中随机选择了2000名年龄在18-75岁的患者，将PFSDQ2发送给他们。经过验证的问卷调查表还附有其他问题，以确定人口统计学，所涉食物和发病年龄。结果：3590名受试者返回了完整的调查表，每次练习的平均回报率为36％（范围为22-47％）。其中有73例根据问卷调查（PFS + ve）被诊断为PFS，人口患病率为2％。另有482名受试者报告了对食物的反应，但未达到PFS的诊断标准。 PFS的最高流行发生在克罗伊登（英格兰东南部）的城市实践中（4.1％），最低的是阿伯丁（苏格兰）的城市实践（0.8％）（P <0.001）。最常见的触发食物是苹果，榛子和猕猴桃，大多数患有PFS的人最初都在20岁以下出现症状。与未对食物有反应的受试者相比，PFS + ve受试者更可能是女性，并且具有较高的社会经济地位。结论：英国的PFS患病率为2％，尽管根据实际人群的位置而有所不同。大多数PFS + ve受试者在青少年时期就首先报告了症状。报道的发病年龄对诊断青少年和年轻人的原发性和交叉反应性花生及坚果过敏具有重要意义。气敏变应原的持续升高很可能导致初级和二级医疗中出现PFS的频率增加。

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