Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells' activity

Serra-Pages M.; Torres R.; Plaza J.; Herrerias A.; Costa-Farre C.; Marco A.; Jimenez M.; Maurer M.; Picado C.; de Mora F.

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Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells' activity

机译：前列腺素E2受体EP2的激活通过抑制肥大细胞的活性来防止屋尘螨引起的气道反应过度和炎症

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Background Prostaglandin E-2 (PGE(2)) has been proposed to exert antiasthmatic effects in patients, to prevent antigen-induced airway pathology in murine models, and to inhibit mast cells (MC) activity in vitro.

机译：背景技术前列腺素E-2（PGE（2））已被提议在患者中发挥抗哮喘作用，在鼠模型中预防抗原诱导的气道病理，并在体外抑制肥大细胞（MC）活性。

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《Clinical and experimental allergy :》 |2015年第10期|共11页
作者
Serra-Pages M.; Torres R.; Plaza J.; Herrerias A.; Costa-Farre C.; Marco A.; Jimenez M.; Maurer M.; Picado C.; de Mora F.;
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正文语种 eng
中图分类医学免疫学;
关键词
allergy; asthma; EP2 receptor; house dust mite; mast cells; PGE2;

机译：过敏;哮喘;EP2受体;屋尘螨;肥大细胞;PGE2;

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专利

1. Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells' activity [J] . Serra-Pages M., Torres R., Plaza J., Clinical and experimental allergy : . 2015,第10期

机译：前列腺素E2受体EP2的激活通过抑制肥大细胞的活性来防止屋尘螨引起的气道反应过度和炎症
2. Subcutaneous prostaglandin E(2) restrains airway mast cell activity in vivo and reduces lung eosinophilia and Th(2) cytokine overproduction in house dust mite-sensitive mice. [J] . Herrerias A, Torres R, Serra M International archives of allergy and immunology . 2009,第4期

机译：皮下前列腺素E（2）在体内抑制气道肥大细胞活性，并减少屋尘螨敏感小鼠的肺嗜酸性粒细胞增多和Th（2）细胞因子过度产生。
3. Extracellular superoxide dismutase ameliorates house dust mite-induced atopic dermatitis-like skin inflammation and inhibits mast cell activation in mice [J] . Lee Yun Sang, Choi Jung-Hye, Lee Ji-Hyun, Experimental dermatology . 2016,第8期

机译：细胞外超氧化物歧化酶改善房屋粉尘螨诱导的特应性皮炎状皮肤炎症，抑制小鼠的肥大细胞活化
4. EP RECEPTOR SUBTYPE-DEPENDENCE OF REGULATION OF IMMUNE CELLULAR FUNCTIONS BY PROSTAGLANDIN E2~a [C] . Li Zeng, Songzhu An, Edward J. Goetzl International Washington Spring Symposium . 1996

机译：EP受体亚型 - 前列腺素e2〜a调节免疫细胞功能的依赖性
5. Conjunctival mast cell modulation of conjunctival epithelial cell activity in ocular allergic inflammation: Effect of mast cell stabilization and role of TNFalpha. [D] . Cook, Ellen Burleigh. 2003

机译：眼变应性炎症中结膜肥大细胞对结膜上皮细胞活性的调节：肥大细胞稳定作用和TNFalpha的作用。
6. Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4 [O] . Ivonne Torres-Atencio, Erola Ainsua-Enrich, Fernando de Mora, 2010

机译：前列腺素E2通过前列腺素受体EP2和EP4阻止高渗诱导的人类肥大细胞活化
7. Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4. [O] . Torres-Atencio Ivonne, Ainsua-Enrich Erola, Mora. Fernando de, 2015

机译：前列腺素E2通过前列腺素受体EP2和EP4阻止高渗诱导的人类肥大细胞活化。

Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells' activity

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