• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma
【24h】

Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma

机译：对孟鲁司特的反应性与支气管高反应性和总免疫球蛋白E相关，但与韩国运动诱发性哮喘儿童白三烯C4合酶和半胱氨酰白三烯受体1基因的多态性无关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: As previous studies have shown that cysteinyl leukotrienes are important mediators in exercise-induced bronchoconstriction (EIB), and leukotriene receptor antagonists (LTRAs) such as montelukast have been shown to improve post-exercise bronchoconstrictor responses, we herein investigated whether clinical responsiveness to montelukast was associated with polymorphisms in the genes encoding leukotriene C4 synthase (LTC4S) and cysteinyl leukotriene receptor 1 (CysLTR1) and/or clinical parameters in Korean asthmatic children with EIB. METHODS: The study population consisted of 100 asthmatic children with EIB. The individuals studied were given exercise challenge tests before and after receiving montelukast (5 mg/day) for 8 weeks. Responders were defined as children showing>10% post-treatment improvement in forced expiratory volume in 1 s (FEV1). The LTC4S A(-444)C and CysLTR1 T(+927)C polymorphisms were genotyped by PCR-restriction fragment length polymorphism analysis. RESULTS: Of 100 enrolledchildren, 68 were classified as responders and 32 were classified as non-responders. No significant association was observed between montelukast responsiveness and LTC4S or CysLTR1 genotype, either alone or in combination. In contrast, montelukast-induced improvement in FEV(1) after exercise was correlated with higher pre-treatment PC20 (methacholine) values (r=0.210, P=0.036) and lower total IgE levels (r=-0.216, P=0.031). CONCLUSIONS: The LTC4S A(-444)C and CysLTR1 T(+927)C genotypes do not appear to be useful for predicting clinical responsiveness to montelukast, whereas bronchial hyperresponsiveness and total IgE appear to predict the degree of montelukast responsiveness in Korean asthmatic children with EIB.
机译：背景：如先前的研究表明，半胱氨酰白三烯是运动诱发的支气管收缩（EIB）的重要介体，并且白三烯受体拮抗剂（孟鲁司特）已显示可改善运动后的支气管收缩反应，我们在此研究了是否对临床反应敏感孟鲁司特与韩国EIB哮喘儿童的白三烯C4合酶（LTC4S）和半胱氨酰白三烯受体1（CysLTR1）的基因多态性和/或临床参数有关。方法：研究人群包括100名EIB哮喘儿童。在接受孟鲁司特（5毫克/天）治疗8周之前和之后，对研究对象进行运动挑战测试。响应者定义为治疗后1秒钟内呼气量提高10％以上的儿童（FEV1）。通过PCR-限制性片段长度多态性分析对LTC4S A（-444）C和CysLTR1 T（+927）C多态性进行基因分型。结果：在100名儿童中，有68名被归类为有反应者，有32名被归类为无反应者。孟鲁司特反应性与LTC4S或CysLTR1基因型（单独或联合使用）之间未观察到显着相关性。相反，孟鲁司特诱导的运动后FEV（1）的改善与治疗前PC20（美沙胆碱）值较高（r = 0.210，P = 0.036）和较低的总IgE水平相关（r = -0.216，P = 0.031）。 。结论：LTC4S A（-444）C和CysLTR1 T（+927）C基因型似乎不能用于预测孟鲁司特的临床反应性，而支气管高反应性和总IgE似乎可以预测韩国哮喘儿童的孟鲁司特反应程度与EIB。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号