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首页> 外文期刊>Clinical and experimental allergy : >Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever.
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Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever.

机译：生命的第一个草花粉季节中的疫苗接种，感染和抗菌剂以及以后发生花粉症的风险。

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BACKGROUND: It has been hypothesized that early-life exposure to vaccinations, infections or antibacterials influence allergic disease development. Concurrent exposure to grass pollens may alter any effect. OBJECTIVE: To test the hypothesis that exposure to antibacterials, vaccinations (DTP or MMR) or specific infections during the first grass pollen seasons of life influences the risk of hayfever more than at any other time of the year. METHODS: Nested case-control studies were based on birth cohorts within two large databases of computerized patient records from UK general practices: the General Practice Research Database (GPRD) and Doctors' Independent Network (DIN). Seven thousand ninety-eight hayfever cases, diagnosed after age 2, were matched to controls for practice, age, sex and follow-up of control to case ascertainment date. Conditional logistic regression was used to compare exposure by age 1 (age 2 for MMR) inside vs. outside the grass pollen season (May, June, July). Odds ratios (ORs) werepooled across databases. RESULTS: There were no associations in either database between MMR during vs. outside the grass pollen season and later hayfever. Of 23 infections studied, none were statistically significant; although analyses for the less common conditions were limited by low statistical power. The pooled OR for hayfever comparing exposure to antibacterials only in the grass pollen season with only outside it was 1.20 (95% CI 0.98-1.47) and for DTP was 0.84 (95% CI 0.72-0.98). CONCLUSION: Although an interaction between early exposure to microbial agents and concurrent grass pollen exposure on hayfever risk seemed plausible, there was little evidence to support it across a range of analyses. However, the effect of DTP though weak deserves further study.
机译：背景：据推测，生命早期接触疫苗，感染或抗菌素会影响过敏性疾病的发展。同时接触花粉可能会改变任何效果。目的：检验以下假设：在生命的头一个草花粉季节中，暴露于抗菌剂，疫苗（DTP或MMR）或特定感染会比一年中其他任何时候对花粉症的影响更大。方法：嵌套病例对照研究是基于英国一般实践的两个大型计算机化患者病历数据库中的出生队列：一般实践研究数据库（GPRD）和医生独立网络（DIN）。在2岁后确诊的798例花粉热病例与对照进行了匹配，包括实践，年龄，性别和对病例确定日期的随访。使用条件逻辑回归分析比较了在花粉季节（5月，6月，7月）内和外的1岁（MMR为2岁）的暴露量。赔率（OR）跨数据库合并。结果：在两个数据库中，MMR在草粉花粉季节以外和以后的花粉热期间之间没有关联。在研究的23种感染中，无统计学意义。尽管对次要条件的分析受制于较低的统计能力。对于花粉症，仅在草花粉季节比较暴露于抗菌剂，而仅在外面，其混合OR为1.20（95％CI 0.98-1.47），而DTP为0.84（95％CI 0.72-0.98）。结论：尽管尽早发现微生物制剂与同时发生花粉引起的花粉接触之间的相互作用似乎是合理的，但在一系列分析中几乎没有证据支持这种相互作用。然而，DTP的作用虽然微弱，但值得进一步研究。

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