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首页> 外文期刊>Clinical and experimental allergy : >Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans.
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Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans.

机译：白细胞介素18基因的单核苷酸多态性和单倍型与特应性皮炎的韩国人。

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摘要

BACKGROUND: IL-18 is a proinflammatory cytokine that plays an important role for T-helper type 1 (Th1) and Th2 cytokine in the presence/absence of IL-12. It has been recently shown that human IL-18 plays a role in atopic dermatitis (AD) by enhancing IL-4 and IL-13 production and by stimulating the synthesis of IgE. OBJECTIVE: We wanted to evaluate the associations of single-nucleotide polymorphism (SNP) and the haplotype in the IL-18 gene, hence we performed genotyping for the SNPs in the IL-18 gene in AD patients and normal controls. METHOD: We genotyped three SNPs from the IL-18 gene for the 1120 case-control samples (646 AD patients and 474 normal controls). We measured the serum IL-18, IL-4 and IL-13 concentrations in 74 individuals (25 ADe, 25 ADi and 24 controls) by performing ELISA. RESULT: The rs795467 SNP and haplotype T-T-C were significantly associated with AD, and especially between the ADe and normal control groups (P=0.03 and 0.01). The serum IL-18 concentration was higher in the AD groupthan in the normal controls without any correlation with the rs795467 polymorphism. We did not find any correlations between the serum IL-18 levels and the SCORing atopic dermatitis index, the blood eosinophil counts and the ECP, and there was no correlation between the serum IL-18 levels and the serum IL-4 and IL-13 levels. CONCLUSION: We found that the one SNP and the haplotype T-T-C were strongly associated with the allergic type of AD, but not with the non-allergic intrinsic type. These data support the hypothesis that IL-18 up-regulates IgE production, yet more experiments will be needed to prove the in vivo involvement of Th2 cytokine.
机译：背景：IL-18是一种促炎性细胞因子，在存在或不存在IL-12的情况下，对于1型T辅助细胞（Th1）和Th2细胞因子都起着重要的作用。最近已经表明，人IL-18通过增强IL-4和IL-13的产生并刺激IgE的合成而在特应性皮炎（AD）中起作用。目的：我们希望评估IL-18基因中单核苷酸多态性（SNP）与单倍型的相关性，因此我们对AD患者和正常对照中IL-18基因中的SNP进行基因分型。方法：我们对来自IL-18基因的3个SNPs进行了1120例病例对照样本（646名AD患者和474名正常对照）的基因分型。通过进行ELISA，我们测量了74名个体（25 ADe，25 ADi和24个对照）的血清IL-18，IL-4和IL-13浓度。结果：rs795467 SNP和单倍型T-T-C与AD显着相关，尤其是在ADe和正常对照组之间（P = 0.03和0.01）。 AD组的血清IL-18浓度高于正常对照组，与rs795467多态性没有任何关系。我们没有发现血清IL-18水平与SCORing特应性皮炎指数，血液嗜酸性粒细胞计数和ECP之间存在任何相关性，并且血清IL-18水平与血清​​IL-4和IL-13之间没有相关性。水平。结论：我们发现一个单核苷酸多态性和单倍型T-T-C与AD的过敏型密切相关，而与非过敏的内在型无关。这些数据支持IL-18上调IgE产生的假说，但是还需要更多的实验来证明Th2细胞因子在体内的参与。

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