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首页> 外文期刊>Clinical and experimental allergy : >Dampness and moulds in relation to respiratory and allergic symptoms in children: Results from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two)
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Dampness and moulds in relation to respiratory and allergic symptoms in children: Results from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two)

机译：与儿童的呼吸道和过敏性症状有关的湿气和霉菌：儿童哮喘和过敏国际研究第二阶段（ISAAC第二阶段）的结果

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Background: Many studies report that damp housing conditions are associated with respiratory symptoms. Less is known about mechanisms and possible effect modifiers. Studies of dampness in relation to allergic sensitization and eczema are scarce. Objective: We study the influence of damp housing conditions world-wide on symptoms and objective outcomes. Methods: Cross-sectional studies of 8-12-year-old children in 20 countries used standardized methodology from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC). Symptoms of asthma, rhinitis and eczema, plus residential exposure to dampness and moulds, were ascertained by parental questionnaires (n = 46 051). Skin examination, skin prick tests (n = 26 967) and hypertonic saline bronchial challenge (n = 5713) were performed. In subsamples stratified by wheeze (n = 1175), dust was sampled and analysed for house dust mite (HDM) allergens and endotoxin. Results: Current exposure to dampness was more common for wheezy children (pooled odds ratio 1.58, 95% CI 1.40-1.79) and was associated with greater symptom severity among wheezers, irrespective of atopy. A significant (P < 0.01) adverse effect of dampness was also seen for cough and phlegm, rhinitis and reported eczema, but not for examined eczema, nor bronchial hyperresponsiveness. HDM sensitization was more common in damp homes (OR 1.16, 1.03-1.32). HDM-allergen levels were higher in damp homes and were positively associated with HDM-sensitization, but not wheeze. Conclusion: A consistent association of dampness with respiratory and other symptoms was found in both affluent and non-affluent countries, among both atopic and non-atopic children. HDM exposure and sensitization may contribute, but the link seems to be related principally to non-atopic mechanisms.
机译：背景：许多研究报告说，潮湿的住房条件与呼吸道症状有关。关于机理和可能的效果调节剂知之甚少。关于过敏性致敏和湿疹的潮湿研究很少。目的：我们研究全球潮湿的住房条件对症状和客观结果的影响。方法：对20个国家/地区的8-12岁儿童进行的横断面研究采用了国际儿童哮喘和变态反应研究（ISAAC）第二阶段的标准化方法。通过父母问卷调查确定哮喘，鼻炎和湿疹的症状，再加上潮湿和霉菌的居住环境（n = 46 051）。进行了皮肤检查，皮肤点刺试验（n = 26 967）和高渗盐水支气管激发（n = 5713）。在通过气喘分层的子样本中（n = 1175），对灰尘进行了采样并分析了屋尘螨（HDM）过敏原和内毒素。结果：当前患湿气的儿童在喘息型儿童中更为常见（比重比为1.58，95％CI为1.40-1.79），并且与喘息症患者的症状严重程度相关，而与特应性无关。对于咳嗽和痰，鼻炎和报告的湿疹，也观察到湿气有明显的不良反应（P <0.01），但对于检查过的湿疹和支气管高反应性则没有。 HDM敏化在潮湿房屋中更为常见（OR 1.16、1.03-1.32）。在潮湿的房屋中，HDM过敏原水平较高，并且与HDM致敏性呈正相关，但与气喘无关。结论：特应性和非特应性儿童中，富裕国家和非富裕国家都发现潮湿与呼吸系统症状和其他症状之间存在相关性。 HDM的暴露和敏化作用可能起作用，但该联系似乎主要与非特应性机制有关。

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