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首页> 外文期刊>Comparative Immunology, Microbiology and Infectious Diseases >Antigenic heterogeneity amongst the field isolates of Newcastle disease virus (NDV) in relation to the vaccine strain. Part II: Studies on viruses isolated from domestic birds in Israel
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Antigenic heterogeneity amongst the field isolates of Newcastle disease virus (NDV) in relation to the vaccine strain. Part II: Studies on viruses isolated from domestic birds in Israel

机译:新城疫病毒(NDV)现场分离株中与疫苗株相关的抗原异质性。第二部分:从以色列家禽中分离出的病毒的研究

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Forty three Newcastle disease virus (NDV) strains isolated before and during 1997 in Israel from domestic birds were studied by means of the three panels of monoclonal antibodies prepared against all the viral envelope proteins in order to reveal the possible antigenic differences between them and the VH strain used in Israel for poultry vaccination. Three isolates were found to have significant antigenic differences in the hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins as compared to the vaccine strain. As to the matrix protein, almost all the viruses isolated during the year 1997 were found to have considerable differences from the vaccine strain in two of four antigenic sites. (C) 2002 Elsevier Science Ltd. All rights reserved. [References: 49]
机译:利用针对所有病毒包膜蛋白制备的三组单克隆抗体,研究了1997年之前和1997年在以色列从家禽中分离出的43种新城疫病毒(NDV)菌株,以揭示它们与VH之间可能的抗原差异在以色列用于家禽疫苗接种的菌株。与疫苗株相比,发现三种分离株在血凝素神经氨酸酶(HN)和融合蛋白(F)糖蛋白上具有明显的抗原差异。至于基质蛋白,发现在1997年分离的几乎所有病毒与疫苗株在四个抗原位点中的两个有很大差异。 (C)2002 Elsevier ScienceLtd。保留所有权利。 [参考:49]

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