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Assessing effects of treatment with lisdexamfetamine dimesylate for pediatric ADHD using a parental survey

机译：使用父母调查评估赖氨苯丙胺二甲磺酸盐治疗小儿多动症的效果

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Introduction: Lisdexamfetamine dimesylate (LDX) is a prodrug stimulant approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in adults and children 6-12 years of age. Parent surveys provide valuable information regarding the impact of ADHD treatments. Methods: Parents of children with ADHD beginning treatment with LDX voluntarily completed surveys through an automated telephone system or the Internet before and 6 weeks after LDX treatment initiation. Prescribing physicians received individual reports of the responses for each survey completed by their patients' parents. All patients whose parents completed both baseline and 6 week surveys were included in the analyses. Subgroup analyses were conducted for those previously treated with medications to treat ADHD, including mixed amphetamine salts-extended release. Results: LDX treatment was associated with a significant decrease in ADHD symptom interference with school activities, family Interactions, homework, and social interactions (P<.01; N=11,576). Parents rated satisfaction with LDX as significantly higher than with their child's previous treatment (P<.01). On average, global improvement, tolerability, convenience, and satisfaction with LDX were all highly rated. Conclusion: Patients treated with LDX showed significant symptom improvement and parents reported significantly greater satisfaction than with prior treatment.
机译：简介：葡糖胺二甲酸酯（LDX）是一种前药兴奋剂，已被批准用于治疗成人和6至12岁儿童的注意力缺陷/多动症（ADHD）。家长调查提供了有关多动症治疗影响的宝贵信息。方法：开始接受LDX治疗的ADHD患儿的父母在开始LDX治疗之前和之后6周通过自动电话系统或互联网自愿完成调查。开处方的医生收到患者父母完成的每次调查的个人报告。所有父母均完成基线和6周调查的患者均纳入分析。对以前用过ADHD药物治疗的患者进行了亚组分析，包括混合的苯丙胺盐延长释放。结果：LDX治疗与注意力缺陷多动障碍症状对学校活动，家庭互动，家庭作业和社交互动的干扰显着减少有关（P <0.01; N = 11,576）。父母对LDX的满意度明显高于对孩子先前的治疗（P <.01）。平均而言，对LDX的整体改进，耐受性，便利性和满意度均得到高度评价。结论：接受LDX治疗的患者症状明显改善，父母报告的满意度明显高于先前治疗。

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