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首页> 外文期刊>CNS spectrums >A horse of a different color: How formulation influences medication effects
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A horse of a different color: How formulation influences medication effects

机译：一匹不同颜色的马：配方如何影响用药效果

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摘要

A medication's pharmacokinetic properties can be as important as its efficacy in determining how successful a treatment is. Formulation plays a critical role in absorption, distribution, and elimination of a drug, which in turn can influence the clinical profile of a medication, including onset and duration of action, consistency of plasma levels, ability to cross the blood-brain barrier, and other factors. Advances in drug delivery technology mean that formulation is now an integral component in the development of a drug. Likewise, formulation is one of the factors that may influence selection of a medication to suit the needs of a particular patient. This article briefly reviews the technologies commonly applied in the development of psychotropic medications, with emphasis on the various oral modified-release formulations, and discusses how formulation can be used to optimize the efficacy and tolerability of psychotropic drugs.
机译：在确定治疗是否成功时，药物的药代动力学特性与其功效一样重要。制剂在药物的吸收，分布和消除中起着关键作用，这反过来又会影响药物的临床特征，包括作用的开始和持续时间，血浆水平的一致性，穿越血脑屏障的能力以及其他因素。药物输送技术的进步意味着制剂现已成为药物开发中不可或缺的组成部分。同样，制剂是可能影响选择药物以适合特定患者需求的因素之一。本文简要回顾了精神药物开发中常用的技术，着重介绍了各种口服调释制剂，并讨论了如何使用该制剂优化精神药物的疗效和耐受性。

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