Metabolites: Novel therapeutics or 'me-too' drugs? Using desvenlafaxine as an example

SchwartzT.L.

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Metabolites: Novel therapeutics or 'me-too' drugs? Using desvenlafaxine as an example

机译：代谢物：新型疗法还是“超效”药物？以去甲文拉法辛为例

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This issue of CNS Spectrums hosts an article that discusses the use of long-term and high-dose desvenlafaxine for treating major depressive disorder (MDD) and a meta-analytic evaluation of this novel, slowrelease metabolite versus its parent compound, the stalwart antidepressant, venlafaxine ER. Over the last decade, the rising cost of healthcare has created debates over the lack of a blockbuster antidepressant pipeline.

机译：本期《 CNS Spectrums》刊登了一篇文章，讨论了长期和大剂量去甲文拉法辛用于治疗重度抑郁症（MDD）的方法，并对这种新型缓释代谢物与其母体化合物，顽固的抗抑郁药进行了荟萃分析评估，文拉法辛ER。在过去的十年中，医疗保健成本的上涨引发了人们对缺乏重磅抗抑郁药管道的争论。

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《CNS spectrums》 |2012年第3期|共4页
作者
SchwartzT.L.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Antidepressants; Desvenlafaxine; Major depressive disorder; Metabolites; Pharmacokinetics; Venlafaxine;

机译：抗抑郁药;去甲文拉法辛;重度抑郁症;代谢产物;药代动力学;文拉法辛;

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专利

1. Metabolites: Novel therapeutics or "me-too" drugs? Using desvenlafaxine as an example [J] . SchwartzT.L. CNS spectrums . 2012,第3期

机译：代谢物：新型疗法还是“超效”药物？以去甲文拉法辛为例
2. Me-too drugs and me-too people [J] . EaglsteinW.H. JAMA dermatology . 2013,第12期

机译：我也是毒品，我也是人民
3. Impact of removal and restriction of me-too medicines in a hospital drug formulary on in- and outpatient drug prescriptions: interrupted time series design with comparison group [J] . Raquel Vázquez-Mourelle, Eduardo Carracedo-Martínez, Adolfo Figueiras Implementation Science . 2019,第1期

机译：在医院药物制质中，除药中的消除和限制的影响：中断时间序列设计与比较组
4. UHPLC-HRMS Method for Repurposing FDA Approved Drugs: Primaquine and its Metabolites as Anticancer Therapeutics [C] . Samantha M. Mahmoud, Dil Ramanathan American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：用于修复FDA批准的药物的UHPLC-HRMS方法：原序及其代谢产物作为抗癌治疗方法
5. Influencing physician prescribing behavior: Direct-to-consumer advertising and the demand for me-too drugs. [D] . Magno-Gatmaytan, Maria Cielo. 2013

机译：影响医师开处方的行为：直接面向消费者的广告以及对超小型药物的需求。
6. Impact of removal and restriction of me-too medicines in a hospital drug formulary on in- and outpatient drug prescriptions: interrupted time series design with comparison group [O] . Raquel Vázquez-Mourelle, Eduardo Carracedo-Martínez, Adolfo Figueiras 2019

机译：医院药物配方中超剂量药物的去除和限制对住院和门诊药物处方的影响：与对照组比较的中断时间序列设计
7. IDENTIFICATION OF DESVENLAFAXINE, THE MAJOR ACTIVE METABOLITE OF VENLAFAXINE, IN EXTENDED-RELEASE CAPSULES [O] . Wilsione Jose Carneiro, Carolina Horta Andrade 2010

机译：在延长释放胶囊中鉴定Desvenlafaxine，venlafaxine的主要活性代谢物

Metabolites: Novel therapeutics or 'me-too' drugs? Using desvenlafaxine as an example

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