Mechanism of action of dextromethorphan/quinidine: Comparison with ketamine

StahlS.M.

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Mechanism of action of dextromethorphan/quinidine: Comparison with ketamine

机译：右美沙芬/奎尼丁的作用机理：与氯胺酮的比较

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ISSUE:Reports of rapid-onset but short-duration antidepressant effects in patients with treatment-resistant mood disorders after intravenous administration of ketamine have prompted efforts to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action. One candidate for this is dextromethorphan, and here the pharmacologic mechanism of action is compared and contrasted with that of ketamine.

机译：问题：氯胺酮静脉注射后对难治性情绪障碍患者具有快速起效但短期的抗抑郁作用的报告促使人们努力寻找具有氯胺酮特性的药物，该药物可以重复剂量口服以维持该作用。一种候选药物是右美沙芬，此处将其作用机理与氯胺酮进行比较和对比。

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《CNS spectrums》 |2013年第5期|共3页
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StahlS.M.;
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正文语种 eng
中图分类神经病学与精神病学;
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1. Mechanism of action of dextromethorphan/quinidine: Comparison with ketamine [J] . StahlS.M. CNS spectrums . 2013,第5期

机译：右美沙芬/奎尼丁的作用机理：与氯胺酮的比较
2. Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. [J] . Sawynok J, Reid A Pain. . 2003,第1a2期

机译：右美沙芬，氯胺酮和阿米替林之间的外周相互作用对大鼠福尔马林诱发的行为和爪水肿的影响。
3. Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine. [J] . Bertelsen KM, Venkatakrishnan K, Von Moltke LL, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2003,第3期

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4. Turbulence-Chemistry Interaction in a Co-axial Methane Diffusion Flame: Comparison of Reaction Mechanisms and Combustion Models [C] . A. Karimi, M. Rajagopal, M. R. Nalim Technical Meeting of the Central States Section of the Combustion Institute . 2012

机译：湍流 - 化学相互作用在共轴甲烷扩散火焰中：反应机制和燃烧模型的比较
5. Neurobiological mechanism of rapid antidepressant actions of ketamine [D] . Li, Nanxin 2011

机译：氯胺酮快速抗抑郁作用的神经生物学机制
6. Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver. [O] . F Broly, C Libersa, M Lhermitte, 1989

机译：奎尼丁对人肝脏微粒体组分右美沙芬O-脱甲基酶活性的影响。
7. A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers [O] . Laura E. Pope, Kerri A. Schoedel, Cynthia Bartlett, 2013

机译：健康志愿者中右美沙芬/奎尼丁和美金刚之间潜在的药代动力学和药效相互作用的研究

Mechanism of action of dextromethorphan/quinidine: Comparison with ketamine

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