• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>エアロゾル研究 >Biopersistence of Japanese Glasswool Fibers in Shorterm Biopersistence Test by letratracheal Instillation
【24h】

Biopersistence of Japanese Glasswool Fibers in Shorterm Biopersistence Test by letratracheal Instillation

机译：气管内滴注法短期玻璃纤维持久性测试中日本玻璃棉纤维的生物持久性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The fiber biopersistence is an important factor in estimating the carcinogenicity and fibrogenicity of fibers. In order to explore the biopersistence of Japanese glasswools in the lung, we examined the clearance of deposited fibers in fibers-exposed rat lungs. The tested fibers were glasswools of GFA10 and GFA20 used conventionally in Japan, and CM44 as the control. Values of KNB (index of Solubility) of GFA10, GFA20 and CM44 were 28.4, 30.3 and 26.74 respectively. Rats were exposed to 2 mg of each fiber intratracheally and sacrificed at 1, 3 days, 2 and 4 weeks after the instillation. The whole lung from the rat was ashed by O2 plasma reactor. The number of recovered fibers longer than 20 jjm in rat lungs was counted using scanning electric microscope (SEM), and the clearance half-times of fibers were calculated by single exponential regression of the fibers. The clearance half-times of fibers with length > 20 pm for GFA10, GFA20 and CM44 from the lung were 9, 8, and 6 days, respectively. The half-times of all glasswools are shorter than 40 days of the clearance half-times in short term biopersistence test by intratracheal instillation regulated by Directive 97/69/EU. SEM microphotographs revealed that recovered fibers had a rough surface and some thin fibers were curled as fibers with high solubility. Taken together, we established the short term biopersistence test by intratracheal instillation, and these data suggested that 2 Japanese glasswools might be biosoluble fibers in the lung.
机译：纤维的生物持久性是评估纤维的致癌性和成纤维性的重要因素。为了探索日本玻璃毛虫在肺中的生物持久性，我们检查了暴露于纤维的大鼠肺中沉积纤维的清除率。所测试的纤维是日本传统使用的GFA10和GFA20的玻璃纤维，而CM44作为对照。 GFA10，GFA20和CM44的KNB（溶解度指数）分别为28.4、30.3和26.74。大鼠在气管内暴露于2 mg的每种纤维中，并在滴注后的1、3天，2和4周处死。用O 2血浆反应器灰化大鼠的整个肺。使用扫描电镜（SEM）对大鼠肺中回收的长于20 jm的纤维数量进行计数，并通过纤维的单指数回归来计算纤维的清除半衰期。长度> 20 pm的纤维从肺中清除GFA10，GFA20和CM44的清除时间分别为9天，8天和6天。在指令97/69 / EU规定的气管内滴注法进行的短期生物持久性测试中，所有玻璃蜡的半衰期均少于清除半衰期的40天。 SEM显微照片显示，回收的纤维具有粗糙的表面，并且一些细的纤维卷曲成具有高溶解度的纤维。综上所述，我们通过气管内滴注建立了短期生物持久性测试，这些数据表明，有2个日本玻璃毛可能是肺中的生物可溶性纤维。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号