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首页> 外文期刊>CNS spectrums >Are the ICD-10 or DSM-5 diagnostic systems able to define those who will benefit from treatment for depression?
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Are the ICD-10 or DSM-5 diagnostic systems able to define those who will benefit from treatment for depression?

机译：ICD-10或DSM-5诊断系统是否能够确定那些将从抑郁症治疗中受益的人？

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摘要

Two widely used diagnostic systems, the International Statistical Classification of Diseases and Related Health Problems (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), are reviewed for their ability to define those who will benefit from active treatment rather than placebo. Both systems suffer from a weakness in defining symptoms sufficiently clearly to separate depression from normal mood variations in the general population. Consequently, normal individuals may be medicalized and defined as suffering from and treated for depression. Also, in mild depression, unlike moderate depression, a lack of significant separation of active treatment from placebo has been shown in individual double-blind, placebo-controlled studies and in meta-analyses of these treatment studies. Both systems would be more useful for treatment purposes if they provided a clearer symptomatic definition of moderate depression, as is widely used in pivotal regulatory standard efficacy studies.
机译：审查了两种广泛使用的诊断系统，即《国际疾病和相关健康问题统计分类》（ICD-10）和《精神疾病诊断和统计手册》第五版（DSM-5），以确定它们将使那些受益者受益的能力。积极治疗而非安慰剂。两种系统的缺点都在于，很难清晰地定义症状以将抑郁与普通人群的正常情绪变化区分开。因此，正常个体可以被医学化并且被定义为患有抑郁症并且对其进行治疗。同样，在轻度抑郁症中，与中度抑郁症不同，在个别的双盲，安慰剂对照研究和这些治疗研究的荟萃分析中已显示出有效治疗与安慰剂之间没有明显分离。如果这两种系统都提供了对中度抑郁症的更清晰的症状定义，那么这两种系统对于治疗目的将更加有用，这已在关键的监管标准功效研究中广泛使用。

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