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首页> 外文期刊>Connective tissue research >Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.
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Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.

机译：透明质酸（HA）和血清来源的透明质酸相关蛋白（SHAP）-HA复合物可作为早产子宫颈成熟的预测指标。

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The purpose of this study is to investigate whether serum hyaluronan (HA) and serum-derived HA-associated proteins (SHAP)-HA complex predict cervical ripening and premature delivery. Sera were obtained from 64 women with normal pregnancies, 20 with full term delivery, and 13 with threatened premature labor. Concentrations of HA and SHAP-HA complex in serum were measured by sandwich ELISA. Serum concentrations of HA and SHAP-HA complex did not differ within first, second, and third trimester groups. The serum SHAP-HA complex was elevated in the full term labor group more than in the third trimester group; however, the concentrations of serum HA did not differ between both groups. The HA and SHAP-HA complex levels in sera were higher in the premature labor group than in the second trimester group. In the premature labor group, the SHAP-HA complex levels were higher in the cases with Bishop scores more than 4 points when compared with the cases with Bishop scores of 4 points or less. Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
机译：这项研究的目的是调查血清透明质酸（HA）和血清来源的HA相关蛋白（SHAP）-HA复合物是否可预测宫颈成熟和早产。血清来自64名正常妊娠的妇女，20名足月分娩的妇女和13名受早产威胁的妇女。通过夹心ELISA测量血清中HA和SHAP-HA复合物的浓度。在孕早期，孕中期和孕晚期，HA和SHAP-HA复合物的血清浓度没有差异。在足月分娩组中，血清SHAP-HA复合物的升高高于妊娠晚期。但是，两组之间的血清HA浓度没有差异。早产组的血清HA和SHAP-HA复合物水平高于孕中期组。在早产组中，Bishop得分大于4分的病例与Bishop得分小于等于4分的病例相比，SHAP-HA复合物水平更高。血清中SHAP-HA复合物水平的升高可能是早产子宫颈成熟的预测指标。

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