A GCN4 Variant with a C-Terminal Basic Region Binds to DNA with Wild-Type Affinity

Jessica J.Hollenbeck; Daniel G.Gurnon; Gia C.Fazio

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A GCN4 Variant with a C-Terminal Basic Region Binds to DNA with Wild-Type Affinity

机译：具有C末端基本区域的GCN4变体与具有野生型亲和力的DNA结合

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Basic-region leucine zipper (bZip) proeins contain a bipartite DNA-binding motif consisting of a leucine zipper dimerization domain and a basic region that directly contacts DNA. In all naturally occurring bZip proteins, the basic region is positioned N-terminal to the leucine zipper.

机译：基本区域亮氨酸拉链（bZip）蛋白包含由亮氨酸拉链二聚化结构域和直接接触DNA的碱性区域组成的二聚体DNA结合基序。在所有天然存在的bZip蛋白中，基本区域位于亮氨酸拉链的N端。

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《Biochemistry》 |2001年第46期|共7页
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Jessica J.Hollenbeck; Daniel G.Gurnon; Gia C.Fazio;
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1. A GCN4 Variant with a C-Terminal Basic Region Binds to DNA with Wild-Type Affinity [J] . Jessica J.Hollenbeck, Daniel G.Gurnon, Gia C.Fazio Biochemistry . 2001,第46期

机译：具有C末端基本区域的GCN4变体与具有野生型亲和力的DNA结合
2. Replacement of invariant bzip residuces within the basic region of the yeast transcriptional activator GCN4 can Change its DNA binding specificity [J] . Benno Müller-Hill, Brigitte Kisters-Woike, Brigitte von Wilcken-Bergmann, Nucleic acids research . 1994,第21期

机译：酵母转录激活因子GCN4基本区域内不变bzip残基的替换可改变其DNA结合特异性
3. The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid [J] . Benno M€ller-Hill, Brigitte von Wilcken-Bergmann, Manfred Suckow Nucleic acids research . 1993,第9期

机译：酵母转录激活因子GCN4基本区域的DNA结合特异性可以通过替换单个氨基酸来改变
4. Design, synthesis and circular dichroism spectroscopy studies on DNA-binding activites of GCN4(226-252) peptide dimer [C] . H.Wang, B.Zhou, Y.Luo, Chinese peptide symposium . 1998

机译：GCN4（226-252）肽二聚体DNA结合活性的设计，合成和圆形二色性光谱研究
5. Study of the expression of Slo1 C-terminal splice variants and functional interaction with binding proteins expressed in the embryonic chick ciliary ganglion [D] . Ridgway, Lon 2008

机译：Slo1 C末端剪接变体的表达及其与雏鸡睫状神经节中表达的结合蛋白的功能相互作用的研究
6. Identification of three residues in the basic regions of the bZIP proteins GCN4 C/EBP and TAF-1 that are involved in specific DNA binding. [O] . M Suckow, B von Wilcken-Bergmann, B Müller-Hill 1993

机译：鉴定bZIP蛋白GCN4C / EBP和TAF-1的基本区域中与特定DNA结合有关的三个残基。
7. The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted (lpha)-helices: Crystal structure of the protein DNA-complex [O] . Dandekar Thomas, Argos P. 2008

机译：GCN4基本区域亮氨酸拉链结合DNA为不间断（ alpha ）螺旋的二聚体：蛋白质DNA复合物的晶体结构

A GCN4 Variant with a C-Terminal Basic Region Binds to DNA with Wild-Type Affinity

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