Residual Electrostatic Effects in the Unfolded State of the N-Terminal Domain of L9 Can Be Attributed to Nonspecific Nonlocal Charge-Charge Interactions

Huan-Xiang Zhou

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Residual Electrostatic Effects in the Unfolded State of the N-Terminal Domain of L9 Can Be Attributed to Nonspecific Nonlocal Charge-Charge Interactions

机译：L9的N末端结构域处于未折叠状态的残余静电效应可归因于非特异性的非局部电荷-电荷相互作用

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Residual electrostatic interactions in the unfolded state of the N-terminal domain of L9 (NTL9) were found by Kuhlman et al. [(1999) Biochemistry 38, 4896-4803]. These residual interactions are analyzed here by the Gaussian-chain model [Zhou, H.-X. (2002) Proc. Natl, Acad. Sci. U.S.A. 99, 3569-3574]. The original model is made more realistic by replacing "standard" model-compound pK_a values for ionizable groups by those measiured by Kuhlman et al. in peptide fragments of NTL9. The predicted pH dependence of the unfolding free energy is in agreement with experiment over the pH range of 1-7 at ionic strengths of 100 and 750 mM. This indicates that the residual electrostatic effects in the unfolded state of NTL9 can be attributed to nonspecific nonlocal charge-charge interactions.

机译：Kuhlman等人发现了L9（NTL9）的N端结构域处于未折叠状态时的残留静电相互作用。 [（1999）Biochemistry 38，4896-4803]。这些残留的相互作用在这里通过高斯链模型[Zhou，H.-X. （2002年）过程。 Natl，Acad。科学美国专利99，3569-3574]。通过用Kuhlman等人的方法代替的那些可电离基团的“标准”模型化合物pK_a值，可以使原始模型更加逼真。在NTL9的肽片段中。在100和750 mM的离子强度下，在1-7的pH范围内，展开自由能的预测pH依赖性与实验一致。这表明在NTL9的未折叠状态下残留的静电效应可归因于非特异性的非局部电荷-电荷相互作用。

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《Biochemistry》 |2002年第20期|共6页
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Huan-Xiang Zhou;
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1. Residual Electrostatic Effects in the Unfolded State of the N-Terminal Domain of L9 Can Be Attributed to Nonspecific Nonlocal Charge-Charge Interactions [J] . Huan-Xiang Zhou Biochemistry . 2002,第20期

机译：L9的N末端结构域处于未折叠状态的残余静电效应可归因于非特异性的非局部电荷-电荷相互作用
2. pKa values and the pH dependent stability of the N-terminal domain of L9 as probes of electrostatic interactions in the denatured state. Differentiation between local and nonlocal interactions. [J] . Kuhlman B, Luisi DL, Young P, Biochemistry . 1999,第15期

机译：LKa的pKa值和L9 N末端结构域的pH依赖性稳定性，可作为变性状态下静电相互作用的探针。本地和非本地交互之间的区别。
3. pKa values and the pH dependent stability of the N-terminal domain of L9 as probes of electrostatic interactions in the denatured state. Differentiation between local and nonlocal interactions. [J] . Kuhlman B, Luisi DL, Young P, Biochemistry . 1999,第15期

机译：LKa的pKa值和L9 N末端结构域的pH依赖性稳定性，可作为变性状态下静电相互作用的探针。本地和非本地交互之间的区别。
4. QCM-Analyses of the Intermolecular Interaction between Prion Protein N-Terminal Domains Having Increased Number of Octapeptide Repeat [C] . Keiko Sato, Yuji Horiuchi, Ayami Matsushima Japanese peptide symposium . 2011

机译：朊病毒蛋白质N-末端域之间分子间相互作用的QCM分析，其八肽重复数量增加
5. Structural and functional studies of interactions between β-1,3-glucan and the N-terminal domains of β;-1,3-glucan recognition proteins involved in insect innate immunity [D] . Dai, Huaien 2013

机译：β-1,3-葡聚糖与参与昆虫先天免疫的β; -1,3-葡聚糖识别蛋白N末端结构域相互作用的结构和功能研究
6. Global analysis of the thermal and chemical denaturation of the N-terminal domain of the ribosomal protein L9 in H2O and D2O. Determination of the thermodynamic parameters deltaH(o) deltaS(o) and deltaC(o)p and evaluation of solvent isotope effects. [O] . B. Kuhlman, D. P. Raleigh 1998

机译：全局分析H2O和D2O中核糖体蛋白L9的N末端结构域的热和化学变性。确定热力学参数deltaH（o）deltaS（o）和deltaC（o）p并评估溶剂同位素效应。
7. Residual Electrostatic Effects in the Unfolded State of the N-Terminal Domain of L9 Can Be Attributed to Nonspecific Nonlocal Charge-Charge Interactions† [O] . 2002

机译：L9的N-末端结构域的未折叠状态下的残余静电效应可归因于非特异性非局域电荷 - 电荷相互作用†

Residual Electrostatic Effects in the Unfolded State of the N-Terminal Domain of L9 Can Be Attributed to Nonspecific Nonlocal Charge-Charge Interactions

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