Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horkoshii

Xinlin Du; Weiru Wang; Rosalind Kim

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Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horkoshii

机译：霍氏热球菌的吡嗪酰胺酶的晶体结构和催化机理

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Bacterial pyrazinamidase (PZAase)icotinamidase converts pyrazinamide (PZA) to ammonia and pyrazinoic acid, which is active against Mycobacterium tuberculosis. Loss of PZAase activity is the major mechanism of pyrazinamide-resistance by M.tuberculosis.

机译：细菌吡嗪酰胺酶（PZAase）/烟酰胺酰胺酶将吡嗪酰胺（PZA）转化为氨和吡嗪酸，对结核分枝杆菌有活性。 PZAase活性的丧失是结核分枝杆菌抵抗吡嗪酰胺的主要机制。

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《Biochemistry》 |2001年第47期|共7页
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Xinlin Du; Weiru Wang; Rosalind Kim;
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1. Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horkoshii [J] . Xinlin Du, Weiru Wang, Rosalind Kim Biochemistry . 2001,第47期

机译：霍氏热球菌的吡嗪酰胺酶的晶体结构和催化机理
2. Crystal Structure of a Hyperthermophilic Archaeal Acylphosphatase from Pyrococcus horikoshii-Structural Insights into Enzymatic Catalysis,Thermostability,and Dimerization [J] . Yuk-Yin Cheung, Sonia Y.Lam, Wai-Kit Chu, Biochemistry . 2005,第12期

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3. Crystal structure of the ATPPase subunit and its substrate-dependent association with the GATase subunit: a novel regulatory mechanism for a two-subunit-type GMP synthetase from Pyrococcus horikoshii OT3. [J] . Maruoka S, Horita S, Lee W Journal of Molecular Biology . 2010,第2期

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Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horkoshii

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