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首页> 外文期刊>Biochemistry >Structure and Function of Voltage-Dependent Ion Channel Regulatory #beta# Subunits
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Structure and Function of Voltage-Dependent Ion Channel Regulatory #beta# Subunits

机译：电压依赖性离子通道调节＃beta＃子单元的结构和功能

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Voltage-dependent K~+, Ca~(2+), and Na~+ channels play vital roles in basic physiological processes, including management of the action potential, signal tranduction, and secretion. They share the common function of passively transporting ions across cell membranes; thus, it would not be surprising if they should exhibit similarities of both structure and mechanism. Indeed, the principal pore-forming (#alpha#) subunits of each show either exact or aporoximate 4-fold symmetry and share a similar transmembrane topology, and all are gated by changes in membrane potential. Furthermore, these channels all possess an auxiliary polypeptide, designated the #beta# subunit, which plays an important role in their regulation. Despite considerable functional semblences and abilities to interact with structurally similar #alpha# subunits, however, there is considerable structural diversity among the #beta# subunits. In this review, we discuss the similarities and differences in the structures and functions of the #beta# subunits of the voltage-dependent K~+, Ca~(2+), and Na~+ channels.
机译：电压依赖性K〜+，Ca〜（2+）和Na〜+通道在基本生理过程中起着至关重要的作用，包括控制动作电位，信号转导和分泌。它们具有跨细胞膜被动转运离子的共同功能。因此，如果它们在结构和机理上都具有相似性，就不足为奇了。确实，每个的主要成孔（＃alpha＃）亚基显示精确的或阿波肟酸4倍对称性，并具有相似的跨膜拓扑结构，并且都被膜电位的变化控制。此外，这些通道都具有辅助多肽，称为＃beta＃亚基，在其调节中起重要作用。尽管有相当的功能相似性和与结构相似的＃alpha＃亚基相互作用的能力，但是，＃beta＃亚基之间仍存在相当大的结构多样性。在这篇综述中，我们讨论了电压依赖性K〜+，Ca〜（2+）和Na〜+通道的＃beta＃亚基的结构和功能的异同。

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