Is the V3 Loop Involved in HIV Binding to CD4?

Dettin M; Ferranti P; Scarinci C; Picariello G; Di Bello C

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Is the V3 Loop Involved in HIV Binding to CD4?

机译：V3回路是否参与HIV与CD4的结合？

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The entry of the human immunodeficiency virus into cells requires the interaction of the viral envelope glycoprotein gp120 with CD4 and a chemokine receptor. The gp120 binding site has been previously mapped to the Ig-CDR2-like region of CD4 first domain. A second area of this domain (Ig-CDR3-like region) is involved in gp120-CD4 interactions, but its gp120 counterpart remained so far unknown. Using a photoaffinity labeling experiment, we demonstrate that a peptide, mapping the (307-330)m region of HIV-MN-gp120 V3 loop, binds a sequence including a part of the Ig-CDR3-like region. These results may contribute to explain the complex mechanism of human immunodeficiency virus penetration, helping the development of new therapeutic agents.

机译：人类免疫缺陷病毒进入细胞需要病毒包膜糖蛋白gp120与CD4和趋化因子受体相互作用。 gp120结合位点已预先映射到CD4第一域的Ig-CDR2样区域。该域的第二个区域（Ig-CDR3样区域）参与了gp120-CD4相互作用，但迄今为止，其gp120对应物仍是未知的。使用光亲和标记实验，我们证明，映射HIV-MN-gp120 V3环的（307-330）m区域的肽结合了包含Ig-CDR3样区域一部分的序列。这些结果可能有助于解释人类免疫缺陷病毒渗透的复杂机制，有助于开发新的治疗剂。

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《Biochemistry》 |2003年第30期|共6页
作者
Dettin M; Ferranti P; Scarinci C; Picariello G; Di Bello C;
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正文语种 eng
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关键词
HIV; Antigens; CD4; Anterior segmental vein; Loop; binding; 抗原; CD4;

机译：HIV;抗原;CD4;前节静脉;环;结合;抗原;CD4;

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专利

1. Is the V3 Loop Involved in HIV Binding to CD4? [J] . Dettin M, Ferranti P, Scarinci C, Biochemistry . 2003,第30期

机译：V3回路是否参与HIV与CD4的结合？
2. Short Communication: Man1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope [J] . Jan Muzafar, Upadhyay Chitra, Sharma Aman, AIDS Research and Human Retroviruses . 2017,第9期

机译：短期通信：MAN1-2MAN结合抗HIV凝集素增强了v1 / v2和V3高变循环的V2i和V3冠中和缺陷的暴露
3. Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies. [J] . Mondor I, Moulard M, Ugolini S, Virology . 1998,第2期

机译：HIV gp120，CD4和CXCR4之间的相互作用：依赖CD4表达水平，gp120病毒起源，gp120 COOH-和NH2-末端以及V1 / V2和V3环的保守性以及对中和抗体的敏感性。
4. 3D models for conformational states of the V3 and V1/V2 loops in gp120/CD4/antibody complex [C] . Stan Galaktionov, Gregory V.Nikiforovich, Garland R.Marshall the International Peptide Symposium . 2001

机译：V3和V1 / V2循环的构象状态的3D模型，GP120 / CD4 /抗体复合物
5. Studies of Protein Interactions and Knowledge-Based Drug Design: (A) The Electrostatic Nature of Recognition Between HIV-1 gp120 V3 Loop and Coreceptors CCR5/CXCR4, (B) Complement System Inhibition by Compstatin Family Peptides [D] . Lopez de Victoria Suarez, Aliana 2012

机译：蛋白质相互作用和基于知识的药物设计的研究：（A）HIV-1 gp120 V3环与共受体CCR5 / CXCR4之间识别的静电性质，（B）坎普他汀家族肽对补体系统的抑制作用
6. Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines [O] . Michael J Bolton, Robert F Garry 2011

机译：间日疟原虫达菲结合蛋白的红细胞结合结构域与HIV-1株MN的V3环之间的序列相似性揭示了功能肝素结合基序该基团与达菲抗原受体的趋化因子结合
7. Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines [O] . Bolton Michael J, Garry Robert F 2011

机译：间日疟原虫达菲结合蛋白的红细胞结合域与HIV-1 MN的V3环之间的序列相似性揭示了一个功能性肝素结合基序，该基团与结合达菲的趋化因子受体有关

Is the V3 Loop Involved in HIV Binding to CD4?

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