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首页> 外文期刊>Biochemistry >Biglutaminyl-Biliverdin IX Alpha as a Heme Degradation Product in the Dengue Fever Insect-Vector Aedes aegypti
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Biglutaminyl-Biliverdin IX Alpha as a Heme Degradation Product in the Dengue Fever Insect-Vector Aedes aegypti

机译：Biglutaminyl-Biliverdin IX Alpha作为登革热昆虫载体埃及伊蚊的血红素降解产物

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摘要

Hemoglobin digestion in the midgut of hematophagous animals results in the release of its prosthetic group,heme,which is a pro-oxidant molecule.Heme enzymatic degradation is a protective mechanism that has been described in several organisms,including plants,bacteria,and mammals.This reaction is catalyzed by heme oxygenase and results in formation of carbon monoxide,ferrous ion,and biliverdin IX alpha.During digestion,a large amount of a green pigment is produced and secreted into the intestinal lumen of Aedes aegypti adult females.In the case of another blood-sucking insect,the kissing-bug Rhodnius prolixus,we have recently shown that heme degradation involves a complex pathway that generates dicysteinyl-biliverdin IX gamma.The light absorption spectrum of the Aedes purified pigment was similar to that of biliverdin,but its mobility on a reverse-phase chromatography column suggested a compound less hydrophobic than biliverdin IXa.Structural characterization by ESI-MS revealed that the mosquito pigment is the a isomer of biliverdin bound to two glutamine residues by an amide bond.This biglutaminyl-biliverdin is formed by oxidative cleavage of the heme porphyrin ring followed by two subsequent additions of glutamine residues to the biliverdin IXa.The role of this pathway in the adaptation of this insect vector to a blood-feeding habit is discussed.
机译：食血动物中肠的血红蛋白消化会导致其辅基血红素的释放，后者是一种促氧化剂分子。血红素酶促降解是一种保护性机制，在包括植物，细菌和哺乳动物在内的多种生物中都有描述。该反应由血红素加氧酶催化，导致形成一氧化碳，亚铁离子和联运蛋白IXα。在消化过程中，会产生大量绿色色素并将其分泌到埃及伊蚊成年女性的肠腔中。最近，另一种吸血昆虫接吻臭虫Rhodnius prolixus的研究表明，血红素降解涉及一个复杂的途径，该途径会生成半胱氨酸-胆红素IXγ。伊蚊精制色素的光吸收光谱与联肝素相似。其在反相色谱柱上的迁移率表明该化合物的疏水性低于联运肝素IXa。通过ESI-MS进行的结构表征表明，蚊子色素是联苯乙肝素的异构体，通过酰胺键与两个谷氨酰胺残基结合，该双谷氨酰胆红素是通过血红素卟啉环的氧化裂解，随后在联乙肝素IXa中再添加两个谷氨酰胺残基而形成的。讨论了该昆虫载体对食血习惯的适应性。

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