Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C

Joyce Chiu; Jason W. H. Wong; Michael Gerometta; Philip J. Hogg

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Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C

机译：重组成熟血管内皮生长因子C的二聚化机理

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The vascular endothelial growth factors (VEGFs) and their tyrosine kinase receptors play a pivotal role in angiogenesis and lymphangiogenesis during development and in pathologies such as tumor growth. The VEGFs function as disulfide-linked antiparallel homodimers. The lymphangiogenic factors, VEGF-C and VEGF-D, exist as monomers and dimers, and dimerization is regulated by a unique unpaired cysteine. In this study, we have characterized the redox state of this unpaired cysteine in a recombinant mature monomeric and dimeric VEGF-C by mass spectrometry. Our findings indicate that the unpaired cysteine regulates dimerization via thioldisulfide exchange involving the interdimer disulfide bond.

机译：血管内皮生长因子（VEGF）及其酪氨酸激酶受体在发育过程中以及诸如肿瘤生长的病理过程中，在血管生成和淋巴管生成中起着关键作用。 VEGF充当二硫键连接的反平行同二聚体。淋巴管生成因子VEGF-C和VEGF-D作为单体和二聚体存在，二聚化受独特的未配对半胱氨酸调控。在这项研究中，我们已通过质谱分析表征了这种未配对的半胱氨酸在重组成熟单体和二聚体VEGF-C中的氧化还原状态。我们的发现表明，未配对的半胱氨酸通过涉及二聚体二硫键的巯基二硫键交换调节二聚化。

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来源
《Biochemistry》 |2014年第1期|共3页
作者
Joyce Chiu; Jason W. H. Wong; Michael Gerometta; Philip J. Hogg;
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正文语种 eng
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关键词
Mechanism; Dimerization; Recombinant Mature;

机译：机制;二聚化;重组成熟;

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1. Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C [J] . Joyce Chiu, Jason W. H. Wong, Michael Gerometta, Biochemistry . 2014,第1期

机译：重组成熟血管内皮生长因子C的二聚化机理
2. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms. [J] . Lahteenvuo JE, Lahteenvuo MT, Kivela A, Circulation: An Official Journal of the American Heart Association . 2009,第6期

机译：血管内皮生长因子B通过血管内皮生长因子1和神经纤毛蛋白1依赖的机制诱导心肌特异性血管生成和动脉生成。
3. Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension [J] . Izumi Suzuma, Yasuaki Hata, Allen Clermont Diabetes . 2001,第2期

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4. Three-dimentional Culture of Vascular Endothelial Cells Using Vascular Endothelial Growth Factor-loaded Apatite-fiber Scaffolds with Enhanced Mechanical Property [C] . K. Kayashima, R. Oyama, M. Emoto Symposium and Annual Meeting of International Society for Ceramics in medicine . 2013

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5. The mechanism of regulation of fibroblast growth factor-2 (fgf-2) and vascular endothelial growth factor-a (vegf-a) dependent angiogenesis by junctional adhesion molecule-a (jam-a). [D] . Chatterjee, Sharmila. 2013

机译：通过连接黏附分子-a（jam-a）调节成纤维细胞生长因子2（fgf-2）和血管内皮生长因子-a（vegf-a）依赖性血管生成的机制。
6. Production of bioactive recombinant human myeloid‐derived growth factor in Escherichia coli and its mechanism on vascular endothelial cell proliferation [O] . Longwei Zhao, Shuang Feng, Shen Wang, 2020

机译：大肠杆菌中具有生物活性的重组人骨髓源性生长因子的生产及其对血管内皮细胞增殖的作用机制
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Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C

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