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YAP and TAZ Take Center Stage in Cancer

机译：YAP和TAZ成为癌症的焦点

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摘要

The Hippo pathway was originally identified and named through screening for mutations in Drosophila, and the core components of the Hippo pathway are highly conserved in mammals. In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis. The Hippo pathway was initially thought to be quite straightforward; however, recent studies have revealed that YAP/TAZ is an integral part and a nexus of a network composed of multiple signaling pathways. Therefore, in this review, we will summarize the latest findings on events upstream and downstream of YAP/TAZ and the ways of regulation of YAP/TAZ. In addition, we also focus on the crosstalk between the Hippo pathway and other tumor-related pathways and discuss their potential as therapeutic targets.
机译：Hippo途径最初是通过对果蝇中的突变进行筛选来确定和命名的，在哺乳动物中，Hippo途径的核心成分高度保守。在河马途径中，MST1 / 2和LATS1 / 2调节下游转录共激活因子YAP和TAZ，它们主要与TEAD家族转录因子相互作用，以促进组织增殖，正常和癌症干细胞的自我更新，迁移和癌变。最初，人们认为河马之路很简单。但是，最近的研究表明，YAP / TAZ是由多个信号通路组成的网络的组成部分和联系。因此，在这篇综述中，我们将总结有关YAP / TAZ上游和下游事件以及YAP / TAZ调控方式的最新发现。此外，我们还关注河马途径与其他肿瘤相关途径之间的串扰，并讨论它们作为治疗靶标的潜力。

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