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首页> 外文期刊>Biomaterials >APATITE LAYER-COATED TITANIUM FOR USE AS BONE BONDING IMPLANTS
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APATITE LAYER-COATED TITANIUM FOR USE AS BONE BONDING IMPLANTS

机译：磷灰石层涂层钛，用作骨结合植入物

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摘要

For development of thin bioactive coatings on metal implants, a dense and uniform apatite layer was coated onto titanium (Ti) implants in situ by using a new biomimetic method, which is composed of apatite nucleation and growth steps in simulated body fluid (SBF). Analysis of the coatings by thin film X-ray diffraction and scanning electron microscopy-energy dispersive X-ray microanalysis (SEM-EMPA) before implantation showed that its characteristics were very similar to those of natural bone. The coated and uncoated rectangular plates were bilaterally implanted into the tibial proximal metaphyses of rabbits. After 6, 10 and 25 weeks post-implantation, the bone bonding and bone formation at the bone-implant interfaces were evaluated by a detachment test and undecalcified histological examination. Mechanical testing in tension showed that the failure load of apatite layer-coated Ti implants was significantly higher than that of uncoated control at each time period (all P < 0.001). Histologically, it was shown that bone was deposited directly onto the apatite coating without any intervening soft tissue, while in the paired controls, interpositional soft tissue was seen at the bone-implant interface. By SEM-EPMA, a uniform calcium- and phosphorus-rich layer was detected between the coated implants and bone, but not in uncoated controls at either earlier or later time periods. The results indicate that the apatite layer deposited on Ti in situ may significantly increase the bone bonding strength by providing a bioactive surface, which allows for an early bone apposition to the implant. In addition, the apatite layer-coated Ti produced by the biomimetic process may fulfil the requirements of favourable thin coatings and strong adhesion at the metal-coating interface. (C) 1997 Elsevier Science Limited. All rights reserved. [References: 30]
机译：为了在金属植入物上开发薄的生物活性涂层，使用一种新的仿生方法将致密且均匀的磷灰石层原位涂覆到钛（Ti）植入物上，该方法由模拟体液（SBF）中的磷灰石成核和生长步骤组成。植入前通过薄膜X射线衍射和扫描电子显微镜-能量色散X射线显微分析（SEM-EMPA）对涂层进行分析，结果表明其特性与天然骨骼非常相似。将涂覆的和未涂覆的矩形板双向植入兔子的胫骨近端干phy端。植入后6、10和25周后，通过脱离试验和未脱钙的组织学检查评估骨-植入物界面处的骨结合和骨形成。在张力下的机械测试表明，在每个时间段，磷灰石层涂覆的Ti植入物的破坏载荷均显着高于未涂覆的对照组（均P <0.001）。从组织学上看，骨骼直接沉积在磷灰石涂层上，而没有任何中间软组织，而在配对对照中，在骨-植入物界面处发现了间质软组织。通过SEM-EPMA，在涂覆的植入物和骨骼之间检测到均匀的富含钙和磷的层，但在较早或较晚的时间中未涂覆的对照中均未检测到。结果表明，原位沉积在Ti上的磷灰石层可通过提供生物活性表面来显着提高骨骼粘结强度，从而使骨骼尽早与种植体并置。此外，通过仿生工艺生产的磷灰石涂层钛可满足良好的薄涂层和在金属涂层界面的牢固附着力的要求。 （C）1997 Elsevier Science Limited。版权所有。 [参考：30]

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