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首页> 外文期刊>Biomaterials >Preparation of poly(epsilon-caprolactone)/continuous bioglass fibre composite using monomer transfer moulding for bone implant.
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Preparation of poly(epsilon-caprolactone)/continuous bioglass fibre composite using monomer transfer moulding for bone implant.

机译:使用用于骨植入物的单体传递模塑法制备聚(ε-己内酯)/连续生物玻璃纤维复合材料。

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摘要

Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre surface. Surface initiated polymerisation significantly improved the Young's modulus and flexural strength and water resistance of the composite. Initial in vitro biocompatibility assessment suggests that amine ended silane treatment of bioglass fibres before their inclusion in the composite does not have a negative effect on the biological responses in terms of macrophage activation as measured by IL-1beta release and craniofacial osteoblast attachment.
机译:聚(ε-己内酯)(PCL)/连续生物玻璃纤维复合材料是使用单体传递模塑技术与表面引发的聚合反应制备的。为了使ε-己内酯从纤维表面聚合,将生物玻璃纤维用胺封端的硅烷进行表面处理。表面引发的聚合反应显着改善了复合材料的杨氏模量,弯曲强度和耐水性。初步的体外生物相容性评估表明,在将生物玻璃纤维包含在复合材料中之前,胺结束了对有机玻璃纤维的硅烷处理,对巨噬细胞活化的生物学反应没有负面影响,如通过IL-1β释放和颅面成骨细胞附着测量。

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