Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review

WuJ.; XueX.; WuZ.; ZhaoH.-L.; CaoH.-M.; SunD.-Q.; WangR.-M.; SunJ.; LiuY.; GuoR.-C.

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Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review

机译：丹皮酚通过调节NF-κB，AKT和MAPKs激活的抗肿瘤作用：快速回顾

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Paeonol, an active component extracted from Chinese herbs, Moutan cortex and Cynanchum paniculatum, has been characterized for its various biological activities, including sedation, hypnosis, anti-inflammatory, anti-allergic, and immunoregulation. Recently, paeonol was investigated to regulate the signalling pathways, including NF-κB, PI3K/PTEN/AKT and ERK/JNK/P38/MAPKs activations, which have been proposed to inhibit apoptosis and induce proliferation in human cancer. In this review, we summarized the literature documenting the involvement of the relationship between anti-tumor effect of paeonol and those signalling pathways.

机译：丹皮酚是从中草药，牡丹皮和山茱Cy中提取的活性成分，具有多种生物活性，包括镇静，催眠，抗炎，抗过敏和免疫调节。最近，研究了丹皮酚来调节信号传导途径，包括NF-κB，PI3K / PTEN / AKT和ERK / JNK / P38 / MAPKs的激活，这些信号通路被认为可以抑制人类癌症的凋亡并诱导其增殖。在这篇综述中，我们总结了文献记录了丹皮酚的抗肿瘤作用与那些信号通路之间的关系。

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《Biomedicine & preventive nutrition》 |2014年第1期|共6页
作者
WuJ.; XueX.; WuZ.; ZhaoH.-L.; CaoH.-M.; SunD.-Q.; WangR.-M.; SunJ.; LiuY.; GuoR.-C.;
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正文语种 eng
中图分类营养卫生、食品卫生;
关键词
Anti-tumor; ERK/JNK/P38/MAPKs; NF-κB; Paeonol; PI3K/PTEN/AKT;

机译：抗肿瘤;ERK / JNK / P38 / MAPKs;NF-κB;丹皮酚;PI3K / PTEN / AKT;

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1. Ethanol extract of Chondracanthus tenellus (Harvey) Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB, MAPKs, and PI3K/Akt signaling pathways [J] . Da Hye Kwon, Yung Hyun Choi, Cheol Park, 亚太热带生物医学杂志（英文版） . 2021,第010期
2. Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review [J] . WuJ., XueX., WuZ., Biomedicine & preventive nutrition . 2014,第1期

机译：丹皮酚通过调节NF-κB，AKT和MAPKs激活的抗肿瘤作用：快速回顾
3. Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways [J] . Wei ZHANG, Bello Babatunde KAZEEM, Haitao YANG, 浙江大学学报（英文版）（B辑：生物医学和生物技术） . 2021,第009期

机译：Aeromonas Sobria通过激活MAPK，AKT和NF-κB途径调节小鼠巨噬细胞的促炎症免疫应答
4. Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-??B pathway [J] . BaoM.-H., ZhangY.-W., ZhouH.-H. Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2013,第2期

机译：丹皮酚通过激活LOX-1 / p38MAPK /NF-κB途径抑制氧化型低密度脂蛋白诱导的内皮细胞凋亡
5. Activation of MAPK and NF-κB induced by biomaterials in vascular endothelial cells [C] . Jiao Sun, Xinning Mu, Tingting Ding International Conference on Multifunctional Materials and Structures . 2008

机译：血管内皮细胞生物材料诱导MAPK和NF-κB的激活
6. Bruton's tyrosine kinase regulates NF-κB activation and B cell survival by B cell receptor and BAFF-R [D] . Shinners, Nicholas Paul 2007

机译：布鲁顿酪氨酸激酶通过B细胞受体和BAFF-R调节NF-κB活化和B细胞存活
7. Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation [O] . Wenfeng Liu, Shun Huang, Yonglian Li, 2018

机译：甘草中的甘草酸通过阻断MAPK和PI3K / Akt依赖性的NF-κB信号传导通路在TPA诱导的皮肤炎症反应中下调炎症反应
8. 4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways [O] . Yi-Jen Liao, Yuan-Hsi Wang, Chao-Lien Liu, 2020

机译：通过阻断TGF-β1/ SMAD，PDGF-BB / MAPK和AKT信号传导途径来抑制4-甲氧基磺酰基Paeonol抑制肝星状细胞活化和肝纤维化

Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review

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