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首页> 外文期刊>Biomedicine & preventive nutrition >Efficiency of lycopene against reproductive and developmental toxicity of Bisphenol A in male Sprague Dawley rats
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Efficiency of lycopene against reproductive and developmental toxicity of Bisphenol A in male Sprague Dawley rats

机译：番茄红素对雄性Sprague Dawley大鼠双酚A生殖和发育毒性的效率

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Bisphenol A (BPA) is an estrogenic environmental toxicant and it is a globally used endocrine disruptor that is incorporated in many plastic industries. The revelation BPA has been implicated to have perilous consequences on reproductive healthiness in human and experimental animals. Present examination endeavor to appraise a powerful antioxidant lycopene against an estrogenic compound BPA. Healthy adult male Sprague Dawley rats were subjected to Bisphenol A (200. mg/kg body weight) dissolved in corn oil (1. mL) administered orally for 30days. The pathological alterations due to BPA encouraged oxidative stress were evaluated in testis and epidydimis tissues. Simultaneously, adjustments in testicular hormones, sperm characteristic, biological enzymes like antioxidant enzymes, elevated peroxide reactions and enhanced ROS formations were measured in reproductive toxicity rats. Captivatingly, oral administration of lycopene (10. mg/kg body weight) with BPA intoxicated rats reduced the testicular toxic condition, biochemical and morphological changes were brought back to normal. In termination, antioxidant potential of lycopene, ameliorates the changes that are induced by BPA.
机译：双酚A（BPA）是一种雌激素性环境毒物，它是一种全球使用的内分泌干扰物，已被许多塑料工业所采用。启示性双酚A被认为对人类和实验动物的生殖健康具有危害性后果。目前的检查努力评估一种针对雌激素化合物BPA的强效抗氧化剂番茄红素。将健康成年雄性Sprague Dawley大鼠置于口服口服的双酚A（200。mg / kg体重）溶解于玉米油（1. mL）中。在睾丸和附睾组织中评估了由于BPA刺激的氧化应激引起的病理改变。同时，在生殖毒性大鼠中测量了睾丸激素，精子特性，抗氧化酶等生物酶的调节，过氧化物反应的增强和ROS形成的增加。令人着迷的是，将番茄红素（10. mg / kg体重）与BPA中毒的大鼠口服给药可减轻睾丸中毒状况，使生化和形态学变化恢复正常。最后，番茄红素的抗氧化潜力改善了BPA引起的变化。

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